The incidence of diabetic neuropathy increases with the duration of diabetes and the degree of hyperglycaemia. Pain is one of the most common and incapacitating symptoms of diabetic neuropathy and its pharmacological control is complex. The effectiveness of antidepressive agents has been described in different types of neuropathic pain, but their effectiveness, when used as analgesics in painfu...

Recent decades have seen development of research and an increased interest in the psychopharmacology of natural remedies. More than 20 herbal remedies have been identified that may potentially be applied in medicine as antidepressive, anxiety relieving or sleep-inducing agents. Patients often prefer to take herbal remedies and often take them on their own, without consulting a physician. The ai...

Background Brexpiprazole is the newest antipsychotic drug approved as an adjunctive for treatment‐resistant depression. This systematic review provides comprehensive, high‐quality evidence effects of brexpiprazole in major depressive disorder (MDD) based on existing and emerging randomised controlled trials (RCTs). Objectives To evaluate benefits harms monotherapy or adjunct treatment acute lon...

BACKGROUND A change in number and/or activity of natural killer cells has repeatedly been reported in depressive illness. Much less attention has yet been given to the subgroup of natural killer cells that are positive for the T-cell marker CD3 (NK-T cells). These cells possibly have important immunoregulatory properties. METHODS We compared number and percentage of NK-T cells (defined as CD3...