Introduction: The Antifibrinolytic Trialists Collaboration aims to increase knowledge about the effectiveness and safety of antifibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials. This article presents the statistical analysis plan for an IPD meta-analysis of the effects of antifibrinolytics for acute intracranial haemorrhage. Methods: The prot...

The Antifibrinolytic Trialists Collaboration aims to increase Introduction knowledge about the effectiveness and safety of antifibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials. This article presents the statistical analysis plan for an IPD meta-analysis of the effects of antifibrinolytics for acute intracranial haemorrhage. : The protocol for...

extensive blood loss in total hip surgery is well known and is associated with a high transfusion rate of allogeneic blood. the aim of this study is to assess the effects of intraoperative tranexamic acid on post-operative bleeding and need for allogeneic transfusion during hip fracture surgery. we investigated 67 patients undergoing hip fracture surgery in a prospective, randomized, double-bli...

There are effective alternatives to furosemide for the prevention and treatment of exercise-induced pulmonary hemorrhage. They include the nasal strip, concentrated equine serum, and a diet rich in omega-3 fatty acids. Conjugated estrogens and antifibrinolytics may also be effective. Authors’ address: College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506; e-mail: tepp@vet...

Recommendations for resuscitation of patients in early haemorrhagic shock, with active ongoing bleeding, have evolved in recent years. This review covers current theories of the pathophysiology of shock and recommended treatments, including damage control surgery, deliberate hypotensive management, administration of antifibrinolytics, early support of the coagulation system, and the possible ro...