background and purpose: use of curcumin, as a promising antifungal agent, is considered an alternative treatment for fungal infections; however, the low solubility of this agent limits its efficacy. accordingly, in this study, we aimed to evaluate the in vitro and in vivo antifungal activities of dendrosomal nanocurcumin with improved solubility and bioavailability. materials & methods: the in ...

In recipients of hematopoietic stem cell transplants (HSCTs), the mortality associated with invasive fungal infections (IFIs) remains high, despite the introduction of broad-spectrum antifungal agents over the past 2 decades. Preventing exposure to fungal pathogens in this population is impossible; therefore, clinicians have focused on prophylactic use of antifungal agents to prevent IFIs in hi...

Antifungal susceptibility tests are performed on fungi that cause disease, especially if they belong to a species exhibiting resistance to commonly used antifungal agents. Antifungal susceptibility testing is also important for resistance surveillance, for epidemiological studies and for comparing the in-vitro activity of new and existing agents. Dilution methods are used to establish the MICs ...

PURPOSE This in vitro study sought to compare the antifungal activity of melaleuca alternifolia oil and fluconazole mixed with a tissue conditioner. MATERIALS AND METHODS By testing several concentrations of fluconazole and melaleuca oil in Visco-gel, the minimum most effective concentration of each antifungal agent against Candida albicans was determined. Mean inhibition diameter (MID) was u...

Haloprogin was shown to be a highly effective agent for the treatment of experimentally induced topical mycotic infections in guinea pigs. Its in vitro spectrum of activity also includes yeasts, yeastlike fungi (Candida species), and certain gram-positive bacteria. The in vitro and in vivo antifungal activity of haloprogin against dermatophytes was equal to that observed with tolnaftate. The st...

This study analyzed the recent causes, prognosis, and treatment strategies for fungal endophthalmitis. A retrospective review of patients who were diagnosed with fungal endophthalmitis at our center was conducted. The fungal organisms isolated from each patient and the visual prognosis according to the route of infection and treatment method were analyzed. A total of 40 eyes from 30 patients wi...

Ten percentage of vulvovaginal candidiasis (VVC) patients experience development of VVC into recurrent VVC (RVVC), which is caused by incomplete eradication of Candida species that form biofilms alone or with bacteria. The purpose of our study was to investigate the effect of types of biofilms on the virulence and antifungal agent resistance of C. albican species. The biofilm formation rate and...