Antihistamine-induced hepatitis is rare. We present 2 cases of antihistamine-induced hepatitis with autoimmune features, caused by loratidine. One case was confirmed by rechallenge. Identifying and discontinuing the offending agent are essential for treatment.

Background: Acne vulgaris is a common skin disease that affects not only teenagers but also the general population. Although acne is not physically disabling, its psychological impact can be striking, contributing to low self-esteem, depression, and anxiety. As a result, there is a significant demand for effective acne therapies. Antihistamine is a widely used medication to treat several allerg...

The Effect of histamine and some Antihistamine in the motitlity of human semin were studid. It shows that the histamine increases sperm metility, further more H2 antihistamine crimetidine had no effect on sperm motility and classical antihistamines decreased sperm motility , where as the inhibition produced by H antihistamine could be over comed with increasing concentration of histamine. Final...

background: urticaria is a skin disease characterized by pruritic edematous lesions also called wheals. although these lesions are self-limited they may result in lowered quality of life index. by far, the most recognized mechanisms that trigger the progression of this condition are hypersensitivity reactions. as an herbal therapy, plantago major has been named in several references of persian ...

A double blind placebo controlled experiment was conducted measuring the effects of the centrally active antihistamine triprolidine and the peripherally acting antihistamine terfenadine on actual driving performance in a group of experienced women drivers. Triprolidine greatly impaired driving behaviour, whereas terfenadine did not. Triprolidine also impaired subjective and objective measures o...

This review provides an overview of the use of antihistamines in children. We discuss types of histamine receptors and their mechanism of action, absorption, onset and duration of action of first-generation and second-generation H(1)-antihistamines, as well as elimination of H(1)-antihistamines which has important implications for dosing in children. The rationale for the use of H(1)-antihistam...

Promethazine (phenergan) has two methyl groups, which in these derivatives are associated with strong antihistaminic power, while chlorpromazine is a propylamine phenothiazine, which has more marked central nervous system effects but only one-hundredth of the antihistamine potency of promezathine. The Department of Pharmacology at Oxford has pointed out (Burns, 1948; Burns and Dutta, 1948; Dews...

Objective: To compare the efficacy of autologous serum with Antihistamine therapy in treating chronic urticaria.
 Study Design: Quasi-experimental study.
 Place and Duration Study: Dermatology Department, Pak Emirate Military Hospital, Rawalpindi Pakistan, from Jul 2018 to Jan 2019.
 Methodology: One hundred four patients urticaria (≥3 times/ week for ≥6 weeks) ages ranging 16 70...

BACKGROUND Antihistamines are the first line of treatment for chronic spontaneous urticaria. However, there is no effective method to predict whether an antihistamine will have a beneficial clinical effect or not. OBJECTIVE To assess whether the change in histamine-induced wheal and flare measurements 24 hours after administration of antihistamine can predict the efficacy of treatment. METH...