Bottle gourd [(Lagenaria siceraria (Mol.) Stand.] fruit is ascribed with many therapeutic effects. The present study was undertaken to explore the antihyperlipidemic effect of four different extracts viz. petroleum ether, chloroform, alcoholic and aqueous extracts from bottle gourd in Triton-induced hyperlipidemic rats and their hypolipidemic effects in normocholesteremic rats. The study is com...

CONTEXT Knowledge of the trends and possible differences in the use of antihyperlipidemic medications in US patients with coronary heart disease (CHD) is vital in order to stimulate a positive change in the health of society. OBJECTIVE To assess, in the ambulatory setting, the frequency of antihyperlipidemic medication use in US patients with CHD. DESIGN Retrospective, national, cross-secti...

To evaluate the antihyperlipidemic activities of Orengedokuto (OT) and Daio-Orengedokuto (DOT), the inhibitory effects of these polyprescriptions on HMG-CoA reductase and pancreatic lipase and on the rat hyperlipidemic model induced by Triton WR-1339 were measured. OT potently inhibited HMG-CoA reductase but did not inhibit lipase. Among their ingredients, Coptidis Rhizoma was the most potent i...

Diabetes mellitus is a worldwide leading metabolic syndrome, associated with profound alterations in carbohydrate, lipids, lipoproteins and protein metabolisms. Worldwide, traditional practitioners for the treatment of diabetes and its complications use a wide variety of medicinal plants. In the present study the aqueous extract of Tephrosia purpurea leaves (TpALet) was evaluated for its antihy...

Cucumis melo Linn. (Cucurbitaceae) fruits have been used, traditionally, for the treatment of various disorders of heart as Cardioprotective and antiobesity. The aim of the present study was to investigate the possible anti-hyperlipidemic activity of Cucumis melo fruit peel extract in triton induced hyperlipidemia in rats. Chloroform, Methanolic and aqueous extracts of were administered to the ...

The present study was designed to investigate antihyperlipidemic activity of dried pulp of Aloe succotrina leaves in Wistar albino rats. Hyperlipidemia was induced in rats by feeding them high fat diet (HFD) or D-fructose (25% w/v) for 4 successive weeks. From 15th to 28th day, dried pulp (100 and 200 mg/kg, p.o) and atorvastatin (10 mg/kg, p.o.) per se were administered 2 h prior to feeding ra...

Peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand regulates adipocyte differentiation and insulin sensitivity, and exerts antihyperlipidemic and anti-inflammatory effects. However, the mechanisms by which PPAR-γ ligands affect hyperlipidemia with severe acute pancreatitis (SAP) have not been fully elucidated. The present study investigated the effects of rosiglitazone, a PPAR-γ ligan...

High blood cholesterol levels are consistently associated with higher risk of coronary heart disease, and other life-threatening cardiovascular and cerebro-vascular damage, including fatal strokes. In the present study methanolic extract of Annona cherimola was evaluated for its antihyperlipidemic potential. Acute hyperlipidemia was induced by single administration of Triton WR 1339 (Tyloxapol)...

The present study was designed to evaluate the antihyperlipidemic effect of aqueous extract of Achyranthes aspera a in experimental rats fed with diet containing sesame oil. Hyperlipidemia and the effect of Achyranthes aspera in experimental rats were studied by assessing parameters such as cholesterol, phospholipids, freefattyacids and triglycerides in serum, liver, and heart and kidney tissue...

Juniperus communis (Cuppraseae), a coniferous plant widely used as traditional medicine was evaluated for the antidiabetic and antihyperlipidemic activity on Streptozotocin(STZ)-nicotinamide induced diabetic rats. The methanolic extract of Juniperus communis (MEJC) (100mg/kg, 200mg/kg, b.w) was administered orally in diabetic group except the standard group (Glibenclamide 10mg/kg, b.w) and the ...