نتایج جستجو برای: antiinfective agents
تعداد نتایج: 360597 فیلتر نتایج به سال:
INTRODUCTION Combined serendipitous and rational drug-design and -retasking approaches continue to identify many natural and synthetic substances with multipurpose therapeutic properties (Clark, 2013a). Among these substances are Ca2+ modulators capable of attenuating the transmission and severity of viral, bacterial, fungal, and protozoal infections (Clark and Eisenstein, 2013; Clark et al., 2...
Various fungi have the ability to colonize surfaces and to form biofilms. Fungal biofilm-associated infections are frequently refractory to targeted treatment because of resistance to antifungal drugs. One fungus that frequently colonises the respiratory tract of cystic fibrosis (CF) patients is the opportunistic black yeast-like fungus Exophiala dermatitidis. We investigated the biofilm-formin...
Fluoroquinolones are one of the most promising and vigorously pursued areas of contemporary antiinfective chemotherapy depicting broad spectrum and potent activity. They have a relatively simple molecular nucleus, which is amenable to many structural modifications. These agents have several favorable properties such as excellent bioavailability, good tissue penetrability and a relatively low in...
The emergence of multiresistant Gram-negative bacteria requires new therapies for combating bacterial infections. Targeting the biogenesis of virulence factors could be an alternative strategy instead of killing bacteria with antibiotics. The outer membrane (OM) of Gram-negative bacteria acts as a physical barrier. At the same time it facilitates the exchange of molecules and harbors a multitud...
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