introduction: scorpion venom is a source of bioactive peptides, and some antimicrobial peptides (amps) have been found in the venom gland of scorpions. therefore, the discovery of new anti-infective agents is an essential need to overcome the problem of antibiotic resistance of clinical isolates. here, we describe three new cationic amps, including meuvap-6, meuap-18-1, and meupep34 from the ve...

background: ubi 29-41 (a derivative of antimicrobial peptide ubiquicidin) labelled with 99mtc is reported to discriminate between bacterial infections and sterile inflammatory processes. in this study, three lyophilized kit were performed, one of them based on the direct labelling with only sncl2 as reducing agent , and other two based on 6- hydrazinopyridine-3-carboxylic acid (hynic) and trici...

Bacillus velezensis GF610 was isolated from soil in Illinois, USA, and found to produce amyloliquecidin GF610, a potent two-component antimicrobial peptide. We report here the GF610 strain draft genome sequence, which contains 4.29 Mb and an overall GC content of 45.91%.

Recently, antimicrobial peptides have been introduced as potent antibiotics with a wide rangeof antimicrobial activities. They have also exhibited other biological activities, including antiinflammatory,growth stimulating, and anti-cancer activities. In this study, an analog of MagaininII was designed and produced as a recombinant fusion protein. The designed sequence containe...

Electrochemical impedance spectroscopy performed on surface-supported bilayer membranes allows for the monitoring of changes in membrane properties, such as thickness, ion permeability, and homogeneity, after exposure to antimicrobial peptides (AMPs). We show that two model cationic peptides, very similar in sequence but different in activity, induce dramatically different changes in membrane p...

Accurate classification of antimicrobial peptides according to their biological activities will facilitate the design of novel antimicrobial agents and the discovery of new therapeutic targets. In this work, an excellent algorithm of Increment of Diversity with Quadratic Discriminant analysis (IDQD) was proposed to classify antimicrobial peptides with diverse biological activities.

Translocation of cell-penetrating peptides is often promoted by increased content of arginine or other guanidinium groups. However, relatively little research has considered the role of these functional groups on antimicrobial peptide activity. This study compared the activity of three histone-derived antimicrobial peptides-buforin II, DesHDAP1, and parasin-with variants that contain only lysin...

Milk proteins provide a natural source of bioactive peptides with potential health benefits and applications in the food industry. The release of these peptides from milk proteins is achieved either by hydrolysis using digestive proteases or by lactic acid bacteria fermentation. Peptides, particularly those derived from milk proteins, can exert a wide range of nutritional, functional and biolog...