Recent years have seen substantial improvements in life expectancy and access to antimicrobials, especially in low-income and lower-middle-income countries, but increasing pathogen resistance to antimicrobials threatens to roll back this progress. Resistant organisms in health-care and community settings pose a threat to survival rates from serious infections, including neonatal sepsis and heal...

AIMS This study examined 448 Campylobacter strains isolated in 1999 and 2000 from US feedlot cattle for resistance to 12 antimicrobials. METHODS AND RESULTS Isolates were tested for antimicrobial susceptibility using the E-test method. Approximately 60% (n = 267) were resistant to one or more antimicrobials, and 19.6% (n = 88) were resistant to two or more antimicrobials. Of the Campylobacter...

Veterinary antimicrobials are the same as, or closely related to, antimicrobials used in human medicine. In the past this had led to the suggestion that emerging resistance to antimicrobials in human pathogens was associated with the overuse and misuse of antimicrobials in veterinary medicine. The decision whether the antimicrobial therapy is required should be based on the specific basis. This...

OBJECTIVE To evaluate the antimicrobial susceptibility patterns of Salmonella isolates from feedlot cattle. DESIGN Cross-sectional study. SAMPLE POPULATION 263 Salmonella isolates. PROCEDURES Fecal samples were collected from the floor of 2 pens in each of 100 feedlots. Two hundred eighty Salmonella isolates were recovered after bacteriologic culture from 38 pens. Of these, 263 isolates w...

Diverse families of antimicrobial peptides and proteins have been described in oysters. We investigated here how antimicrobials are involved in the immune response against a pathogenic strain of Vibrio splendidus. Oyster antimicrobials were shown to display a wide variety of expression profiles in hemocyte populations and tissues. Oyster defensins are constitutively expressed in specific tissue...

OBJECTIVE To evaluate effect of various regimens for administration of antimicrobials in feed on growth rate and feed efficiency (feed/gain) of pigs in multisite production systems. DESIGN Controlled trial. ANIMALS 24,099 growing pigs in 3 multisite production systems. PROCEDURE 10 trials involving various regimens for administration of antimicrobials in feed were evaluated. Trial 1 compa...