It has been more than 50 years since antinuclear antibodies were first discovered and found to be associated with connective tissue diseases. Since then different methods have been described and used for their detection or confirmation. For many decades immunofluorescent antinuclear antibody test has been the "gold standard" in the diagnosis of these disorders. However to increase the sensitivi...

This study aimed to understand the differences in disease duration, serological parameters, extra Articular Manifestation and treatment of Indian RA patients depending upon antinuclear antibody (ANA) positivity. was planned as a cross-sectional observational study, wherein 184 18 years above diagnosed tested for Antinuclear Antibody, who reported consultation at rheumatology department Medanta ...

Introdução: A pesquisa de autoanticorpos em células HEp-2 através imunofluorescência indireta é o teste padrão atualmente aceite como a ferramenta central para diagnóstico das doenças autoimunes sistémicas. O International Consensus on Antinuclear Antibody (ANA) Patterns tem objetivo principal alcançar um consenso na nomenclatura e descrição dos diferentes padrões morfológicos anticorpos antinu...