نتایج جستجو برای: antisolvent
تعداد نتایج: 420 فیلتر نتایج به سال:
Differences in physical and chemical properties between polymorphic compounds (e.g. solubility, dissolution rate, chemical reactivity, resistance to degradation, bioavailability) are highly significant for the pharmaceutical industry, which requires effective methods to control polymorphism of organic crystals [1, 2]. In particular, to improve the functionality such as solubility or bioavailabi...
In order to enhance solubility and dissolution rate in water, micronized l-nimodipine (NMD) has been successfully prepared by antisolvent re-crystallization process using acetone as solvent and deionized water as antisolvent. The effects of five experimental parameters on the mean particle size (MPS) of NMD nanosuspension were investigated. It was found that the MPS of NMD nanosuspension decrea...
Antisolvent crystallization is a separation technology that separates the solute from solvent by addition of another solvent, in which sparingly soluble. High yields are achieved using higher antisolvent-to-aqueous ratios, but this generates supersaturation, causes excessive nucleation. This results production smaller particles, difficult to handle downstream processes. In work, effect varying ...
size reduction of high energy materials such as 1, 3, 5, 7-tetranitro- 1, 3, 5, 7-tetraaza cyclooctane (hmx) has considerable influences on improving their explosive characteristics. in this study, nanosized hmx particles were produced using ultrasonically reprecipitation method by applying water as a safe and accessible antisolvent instead of unsafe conventional methods. sem photographs revea...
Background This article presents an acoustically enhanced microfluidic mixer to generate highly uniform and ultra-fine nanoparticles, offering significant advantages over conventional liquid antisolvent techniques. Methods The method employed a 3D microfluidic geometry whereby two different phases - solvent and antisolvent - were introduced at either side of a 1 μm thick resonating membrane, ...
Size reduction of high energy materials such as 1, 3, 5, 7-tetranitro- 1, 3, 5, 7-tetraaza cyclooctane (HMX) has considerable influences on improving their explosive characteristics. In this study, nanosized HMX particles were produced using ultrasonically reprecipitation method by applying water as a safe and accessible antisolvent instead of unsafe conventional methods. SEM photographs revea...
Polyphenols or phenolic compounds are groups of secondary metabolites widely distributed in plants and found in olive mill wastewater (OMW). Phenolic compounds as well as OMW extracts were evaluated in vitro for their antimicrobial activity against Gram-positive (Streptococcus pyogenes and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae). Most of th...
The aim of this study was to prepare nanosized Tripterygium wilfordii multi-glycoside (GTW) powders by the supercritical antisolvent precipitation process (SAS), and to evaluate the anti-inflammatory effects. Ethanol was used as solvent and carbon dioxide was used as an antisolvent. The effects of process parameters such as precipitation pressure (15-35 MPa), precipitation temperature (45-65 °C...
in this study, confined impinging liquid jets are used to produce nanoparticles of carbamazepine (cbz). the effect of operating parameters, such as the kind of solvent,cbz concentration, flow rate of solution and antisolvent on particle size, are experimentally investigated. the scanning electron micrograph (sem) photomicrographs show that nanodrug with smaller particle is achievable by using s...
Systematic nonlinear optimisation is a valuable tool towards evaluating the performance of conceptual Continuous Pharmaceutical Manufacturing (CPM) flowsheets. This study considers total cost minimisation of multiple plausible design choices and eight candidate antisolvents for the continuous recovery of artemisinin (a potent antimalarial Active Pharmaceutical Ingredient/API) via continuous cry...
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