? columns the tendency to draw far reaching conclusions on inadequate grounds purporting to be based on experimental data, I take the opportunity offered by Major Carr-Whiteis interesting paper " Is Antivenene of any value in Cobra Poisoning, in your current number to again draw attention to this important matter in relation to the anti-toxins, taking for illustration anti-venene, anti-tet ino-...

Programmed cell death in bacteria is generally associated with two-component toxin-antitoxin systems. The SpoIISABC system, originally identified in Bacillus subtilis, consists of three components: a SpoIISA toxin and the SpoIISB and SpoIISC antitoxins. SpoIISA is a membrane-bound protein, while SpoIISB and SpoIISC are small cytosolic antitoxins, which are able to bind SpoIISA and neutralize it...

Bacterial toxin-antitoxin (TA) systems typically consist of a small, labile antitoxin that inactivates a specific longer-lived toxin. In Escherichia coli, such antitoxins are proteolytically regulated by the ATP-dependent proteases Lon and ClpP. Under normal conditions, antitoxin synthesis is sufficient to replace this loss from proteolysis, and the bacterium remains protected from the toxin. H...

We prepared antitoxins specific for each of two toxins of Clostridium difficile and used these to demonstrate that the toxins are immunologically distinct.

introduction botulism is an acute form of poisoning resulted from ingestion of clostridium botulinum toxin. case presentation here we present five cases of food-borne botulism poisoning from home produced cheese. five patients from one family referred to our emergency unit with complaints of weakness and two had severe symptoms. in spite of the laboratory negative results antitoxin was administ...