5-Arylisoxazolyl-3-carboxaldehydes were condensed with N-aryl acetoaceta¬mide and ammonium acetate in methanol to give N3,N5-diaryl-4-(5-arylisoxazol-3-yl)-1,4-dihydropyridine-3,5-dicarboxamides. All compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H37Rv). The results for new synthesized compounds showed a moderate activity in comparison to rifampicin.

A series of 4-(2,5-dimethylpyrrol-1-yl)/4-pyrrol-1-yl benzoic acid hydrazide analogs, some derived triazoles, azetidinones, thiazolidinones, and pyrroles have been synthesized in good yields and structures of these compounds were established by IR, (1)H NMR, (13)C NMR, mass spectral, and elemental analysis. These compounds were evaluated for their preliminary in vitro antibacterial, antifungal,...

This study was aimed with an objective to investigate the antimicrobial, antifungal and antitubercular activity of different parts of Adansonia digitata L. The leaves, Root bark, and Fruit pulp were extracted with methanol. The antibacterial and antifungal activity of the extracts were determined using Broth dilution and Agar disc diffusion method and antitubercular activity was determined usin...

Aryl and heteroaryl derivatives with an alkylaminoethyl chain on the hydroxyl group of the benzene ring are prepared and evaluated against Mycobacterium tuberculosis H37Rv and showed the activity in the range of 3.12-25 μg/mL. The compounds containing alkylaminoethyl chains on aryl-chromeneyl carbinol do not show good activity. Similarly compounds with bis and tris-alkylaminoethyl chains on ary...

A series of 2-((arylamino)methyl)-5-(3-methoxyphenyl)-1-phenyl-1H-1,2,4-triazole-3-thione derivatives have been synthesized and characterized by FT-IR, NMR, mass spectral and elemental analysis. Compounds (MM4a-m) have been evaluated for their in vitro antibacterial activity against selected gram-positive and gram-negative bacteria and in vitro antifungal activity against fungal pathogens by us...

Tuberculosis still remains a leading cause of death in the world. Currently considerable interest in natural products and their derivatives in the area of drug research for multidrug resistant tuberculosis (MDR-TB). The present investigation focused on identification, isolation, characterization of lead constituents and to determine the antitubercular activity of their enriched fractions and is...

Tuberculosis still remains a leading cause of death in the world. Currently considerable interest in natural products and their derivatives in the area of drug research for multidrug resistant tuberculosis (MDR-TB). The present investigation focused on identification, isolation, characterization of lead constituents and to determine the antitubercular activity of their enriched fractions and is...

As a part of our research to develop novel antimicrobial and antitubercular agents, a series of 4-(2-aryl-4-oxo-1,3thiazolidine)-5-mercapto-3-(5-nitroindazolyl methyl)-1,2,4triazoles (5a-j) have been synthesized by conventional as well as microwave method. The structures of these compounds were confirmed by IR, H NMR, C NMR, FABmass spectra and also by microanalytical data. These compounds were...

Reaction of 2-hydrazinocarbonyl-3-chloro-5-phenoxy-benzo[b] thiophene with different substituted phenyl isothiocyanate gave N-substituted arylthiosemi-carbazide derivatives (1a-h). 1,3,4-Thiadiazole derivatives (2a-h) were prepared by the cyclization of arylthiosemicarbazides (1a-h) with concentrated sulphuric acid. All the compounds were screened for their antitubercular activity against Mycob...