The hepatitis B virus (HBV) core protein is essential for HBV replication and an important target for antiviral drug discovery. We report the first, to our knowledge, high-resolution crystal structure of an antiviral compound bound to the HBV core protein. The compound NVR-010-001-E2 can induce assembly of the HBV core wild-type and Y132A mutant proteins and thermostabilize the proteins with a ...

Aims: This paper aimed to investigate the antiviral drugs against Sars-Cov-2 main protease (MPro) using in silico methods.
 Material and Method: A search was made for PubChem database such as Bictegravir, Emtricitabine, Entecavir, Lamivudine, Tenofovir, Favipiravir, Hydroxychloroquine, Lopinavir, Oseltamavir, Remdevisir, Ribavirin, Ritonavir were included our study. The protein structure o...

The spike protein of SARS-CoV-2 harbours a cleavage motif for host cell proteases that is not found in closely related viruses. Peacock and colleagues show this allows the virus to evade innate antiviral defences required transmission.

A new study shows that the SARS-CoV-2 nucleocapsid protein represses antiviral type I interferon response through direct interaction with signalling adaptor MAVS. Targeting this process might be a useful therapeutic strategy to boost immunity against COVID-19.

Pokeweed antiviral protein is an enzyme of Mr 29,000 known to inactivate a wide variety of eukaryotic ribosomes. We have used electron microscopy to show that the antibody specific for the protein is bound within the cell wall matrix of leaf mesophyll cells from Phytolacca americana. Any penetration or breakage of the cell wall and membrane could allow the enzyme to enter the cytoplasm, where i...

To defend cells against viruses, the MAVS (mitochondrial antiviral signaling) adaptor protein initiates an antiviral signaling cascade from mitochondrial membranes. In this issue, Dixit et al. (2010) show that MAVS also localizes to the membranes of peroxisomes, where it rapidly induces expression of a subset of antiviral genes that curb viral replication until mitochondrial MAVS can induce a s...

Venom from different organisms was used in ancient times to treat a wide range of diseases, and combat variety enveloped non-enveloped viruses. The aim this silico research investigate the impact honeybee venom proteins peptides against Ebola virus. In current study, online offline tools were used. RaptorX (protein 3D modeling) PatchDock (protein–protein docking) as tools, while Chimera LigPlot...

We previously found that enveloped virus binding and penetration are necessary to initiate an interferon-independent, IRF3-mediated antiviral response. To investigate whether membrane perturbations that accompany membrane fusion-dependent enveloped-virus entry are necessary and sufficient for antiviral-state induction, we utilized a reovirus fusion-associated small transmembrane (FAST) protein....