Cardiovascular Risk? To the Editor: We have read the article by Kiechl et al1 demonstrating that acquired activated protein C resistance (APC) may be a risk factor for atherosclerosis and arterial thrombosis in whites. We2 previously demonstrated that acquired APC resistance is associated not only with venous thrombosis (deep vein thrombosis and pulmonary thromboembolism) but also with arterial...

Key words: anticoagulation; APC resistance; protein S autosomal dominant trait [6 ] in >90% of cases with APC resistance [7]. Some reports suggested that there deficiency; renal failure; shunt thrombosis must also be another cause for APC resistance apart from the FV Leiden mutation [8]. A recent publication described a new mutation: FV Cambridge [9]. This is

An important risk factor for thrombosis is the polymorphism R506Q in factor V that causes resistance of factor Va to proteolytic inactivation by activated protein C (APC). To study the potential influence of the carbohydrate moieties of factor Va on its inactivation by APC, factor V was subjected to mild deglycosylation (neuraminidase plus N-glycanase) under nondenaturing conditions. The APC re...

Resistance to activated protein C (APC), which is the most prevalent pathogenetic risk factor of thrombosis, is linked to a single point-mutation in the factor V (FV) gene, which predicts replacement of Arg (R) at position 506 with a Gln (Q). This mutation modifies one of three APC-cleavage sites in the heavy chain of activated FV (FVa), suggesting that mutated FVa (FVa:Q506) is at least partia...

BACKGROUND Activated protein C (APC) resistance with or without factor V Leiden (FVL) is a major risk factor for venous thromboembolism. Many previous pregnancy studies have been focused on APC resistance caused by FVL. Very few have investigated APC resistance in the absence of FVL (APCR(FVL-)). MATERIAL AND METHODS In a prospective study of 2480 unselected gravidae, blood was drawn in early...

A poor anticoagulant response to activated protein C (APC r&stance) induced hy the ArglGln8g8 mutation of the Factor V gene is, in ssversl countries, the most oommon genetic defect sssootatsd with thmmbophilic disorders. Frequencies of APC resistance between 2050% have teen observed in pstients with deep venous thrombosis, SugQedinQ the importance of the Pmtein C System acttvity. Also, in other...

BACKGROUND Around 25 million Caucasian women are carriers of the FV Leiden mutation that causes activated protein C (APC) resistance. This is a heritable condition with a lifelong increased risk of venous thromboembolism. We performed this study to investigate women's reactions to their awareness of being APC-resistant and the consequences of this awareness. METHODS All APC-resistant women (n...

A poor anticoagulant response to activated protein C (APC r&stance) induced hy the ArglGln8g8 mutation of the Factor V gene is, in ssversl countries, the most oommon genetic defect sssootatsd with thmmbophilic disorders. Frequencies of APC resistance between 2050% have teen observed in pstients with deep venous thrombosis, SugQedinQ the importance of the Pmtein C System acttvity. Also, in other...