Checkpoint kinase 2 (Chk2) is a major regulator of DNA damage response and can induce alternative cellular responses: cell cycle arrest and DNA repair or programmed cell death. Here, we report the identification of a new role of Chk2 in transcriptional regulation that also contributes to modulating the balance between survival and apoptosis following DNA damage. We found that Chk2 interacts wit...

Endometrial carcinoma (EC) is an epithelial malignant tumor that occurs in the endometrium. It of great significance to explore new targets for improving prognosis endometrial cancer. Chikusetsusaponin Iva (CHI) a plant compound extracted from Panacis japonica which has multiple biological activities, including anti-inflammation and anti-tumor effects. However, its possible effects on EC are un...

Atherosclerosis, restenosis, and posttransplant graft atherosclerosis are characterized by endothelial damage, infiltration of inflammatory cells, and proliferation of smooth muscle cells. The CXCR3-activating chemokines interferoninducible protein 10 (IP10) and MIG (monokine induced by interferon) have been implicated in vascular repair and remodeling. The underlying molecular mechanisms, howe...

Atherosclerosis, restenosis, and posttransplant graft atherosclerosis are characterized by endothelial damage, infiltration of inflammatory cells, and proliferation of smooth muscle cells. The CXCR3-activating chemokines interferon-gamma inducible protein 10 (IP10) and MIG (monokine induced by interferon-gamma) have been implicated in vascular repair and remodeling. The underlying molecular mec...

RATIONALE Oxidants generated by activated endothelial cells are known to induce apoptosis, a pathogenic feature of vascular injury and inflammation from multiple pathogeneses. The melastatin-family transient receptor potential 2 (TRPM2) channel is an oxidant-sensitive Ca2+ permeable channel implicated in mediating apoptosis; however, the mechanisms of gating of the supranormal Ca2+ influx requi...

Background: Nerol was reported as a natural anti-oxidant product and its protective effects against cardiovascular diseases have been documented. Our current study designed to explore the cardioprotective effect of on hypoxia/reoxygenation (H/R)-induced production reactive oxygen species (ROS) cell apoptosis in H9c2 cells. The potential molecular mechanisms were further investigated.
 Meth...

Type 2 diabetes involves insulin resistance and β-cell failure leading to inadequate insulin secretion. An important component of β-cell failure is cell loss by apoptosis. Apoptosis repressor with caspase recruitment domain (ARC) is an inhibitor of apoptosis that is expressed in cardiac and skeletal myocytes and neurons. ARC possesses the unusual property of antagonizing both the extrinsic (dea...

ROS: Reactive Oxygen Species; RONS: Reactive Oxygen Nitrogen Species; TNF: Tumor Necrosis Factor; TNFR: Tumor Necrosis Factor Receptor; NF: Nuclear Factor; COPD: Chronic Obstructive Pulmonary Disease; RHD: Rel Homology Domain; IL: Interleukin; NIK: NF-κB Inducing Kinase; IKK: IκB kinase; BCL: B-Cell Lymphoma; MOD: Minimal Oligomerization Domain; LPS: Lipopolysaccharide; RIP: Receptor Interactin...

BACKGROUND The matrine-type alkaloids are bioactive components extracted from Sophora flavescens, which is used in treatment of diabetes mellitus in traditional Chinese medicine. Advanced glycation end products mediate diabetic vascular complications. This study was aimed to investigate the protective effects and molecular mechanisms of matrine-type alkaloids on advanced glycation end products-...