Background and Objective: The management of apoptotic cell death has been considered as a putative therapeutic strategy for cancer treatment. In the present study we investigated the putative pro-apoptotic effect of allicin, the main garlic organosulfur component with repeatedly claimed chemopreventive potency, on the human adenocarcinoma cell line HT29 as an apoptosis resistant cell line, i...

calprotectin, a calcium-bound protein complex, is abundant in the cytosol of neutrophils. it has been reported that this protein has an apoptotic activity in tumor cells. since calprotectin increases in colorectal cancer, this study was conducted to investigate, for the first time, the cytotoxicity/apoptotic effect of calprotectin on ht29/219 and sw742 colon carcinoma and adenocarcinoma cell li...

Evaluation of Apoptotic Effect Protein Fusion, Enterocin A, R-Type Pyocin, Lactocin, and Specific Ligand on Gastric Cancer Cell Line (AGS)

background and objective: garlic has been known worldwide as a dietary constituent with many pharmacological effects. the present in vitro study was designed to investigate the putative anticancer effect of garlic extract on cancer cells, and if this effect was through apoptosis induction. material and methods:  human colon adenocarcinoma cells ht29 were treated with different doses (1, 5 and 1...

background and aims: epigallocatechin-3-gallate (egcg) is a polyphenolic compound from green tea, which its anticancer effects on many types of cancers have been confirmed, but the molecular mechanism by which egcg induces apoptosis remains unknown. the aim of the present study was to investigate anti-proliferative properties and apoptotic signaling pathway of egcg on pc3 human prostate cancer ...

ophiocoma erinaceus muller &troschel; (ophiocomidae) is part of the extensive group of echinoderm that contains bioactive metabolites. as, the anti cancer potential of brittle star saponin has not been reported against cervical cancer, the present study was conducted to evaluate the anticancer effect of extracted crude saponin. saponin extraction was conducted using conventional method such as ...

Calprotectin, a calcium-bound protein complex, is abundant in the cytosol of neutrophils. It has been reported that this protein has an apoptotic activity in tumor cells. Since calprotectin increases in colorectal cancer, this study was conducted to investigate, for the first time, the cytotoxicity/apoptotic effect of calprotectin on HT29/219 and SW742 colon carcinoma and adenocarcinoma cell li...