antiproliferative protein (app) isolated from conditioned media of two androgen-independent prostatic carcinoma cell lines, pc3 and du-145 was shown to inhibit selectively cell proliferation of androgen-dependent prostate cancer cell line lncap in a dose dependent manner. this protein was further purified with hplc using hydrophobic interaction column (phenyl 5pw) and was used to study the modu...

Background and Objective: Breast cancer patients need a variety of skills and abilities to deal with the consequences of the illness. Self-management is one of the operational strategies that leads to disease acceptance, treatment adherence, and improving the quality of life. The use of smartphone applications (apps) can play a pivotal role in the support and self-management of breast cancer pa...

this paper presents a genetic algorithm (ga) for solving a generalized model of single-item resource-constrained aggregate production planning (app) with linear cost functions. app belongs to a class of pro-duction planning problems in which there is a single production variable representing the total production of all products. we linearize a linear mixed-integer model of app subject to hiring...

background: we investigated the efficacy of a mobile-based  bolus advisor app in comparison with the usual multiple daily  injections (mdis) in diabetic patients. materials and methods: in a nonrandomized, controlled clinical trial, 62 diabetic patients  were selected to receive a 12-week intensive glycemic control by either a mobile-based bolus advisor (app) or mdi in the usual manner.we compa...

in atom transfer radical polymerization (atrp) of methyl acrylate (ma) with polyvinyl acetate macroinitiator in bulk at 90°c the plots of ln [m]0/[m] increased linearly with reaction time. the apparent propagation rate constant (kp app) of the reaction was obtained from the linear curve and used to calculate the free macroradical concentration ([r°]) in polymerization medium. the [r°] and also ...

APP-BP1, first identified as an amyloid precursor protein (APP) binding protein, is the regulatory subunit of the activating enzyme for the small ubiquitin-like protein NEDD8. We have shown that APP-BP1 drives the S- to M-phase transition in dividing cells, and causes apoptosis in neurons. We now demonstrate that APP-BP1 binds to the COOH-terminal 31 amino acids of APP (C31) and colocalizes wit...

Amyloid precursor protein binding protein-1 (APP-BP1) binds to the carboxyl terminus of the amyloid precursor protein (APP) and serves as the bipartite activation enzyme for the ubiquitin-like protein, NEDD8. In the present study, we explored the physiological role of APP-BP1 in the cell cycle progression of fetal neural stem cells. Our results show that cell cycle progression of the cells is a...