نتایج جستجو برای: approval
تعداد نتایج: 24030 فیلتر نتایج به سال:
AIMS Regulatory requirements for new drugs have increased. Special approval procedures with priority assessment are possible for drugs with clear 'unmet medical need'. We question whether these Exceptional Circumstances (EC) or Conditional Approval (CA) procedures have led to a higher probability of serious safety issues. METHODS A retrospective cohort study was performed of new drugs approve...
Title of Dissertation: Efficient Local Algorithms for Distributed Data Mining in Large Scale Peer to Peer Environments: A Deterministic Approach Kanishka Bhaduri, Doctor of Philosophy, 2008 Thesis directed by: Dr. Hillol Kargupta Associate Professor Department of Computer Science and Electrical Engineering Peer-to-peer (P2P) systems such as Gnutella, Napster, e-Mule, Kazaa, and Freenet are incr...
In "Replicating Milgram: Would People Still Obey Today?" Jerry M. Burger reported a high base rate of obedience, comparable to that observed by Stanley Milgram (1974). Another condition, involving a defiant confederate, failed to significantly reduce obedience. This commentary discusses the primary contributions of Burger's study in terms of (a) its novel methodological variation on Milgram's o...
The purposes of our study were to identify a drug entry process, collect, and prioritize criteria for selecting drugs for the list of basic health insurance commitments to prepare an "evidence based reimbursement eligibility plan" in Iran. The 128 noticeable criteria were found when studying the health insurance systems of developed countries. Four parts (involving criteria) formed the first qu...
Traditional drug licensing approaches are based on binary decisions. At the moment of licensing, an experimental therapy is presumptively transformed into a fully vetted, safe, efficacious therapy. By contrast, adaptive licensing (AL) approaches are based on stepwise learning under conditions of acknowledged uncertainty, with iterative phases of data gathering and regulatory evaluation. This ap...
Recent advances in biotechnology have led to discoveries resulting in major improvements in the therapy of refractory malignancies, although most advanced cancers remain incurable. Thus, there is global consensus around the need to streamline the drug approval process for effective agents. Accelerated Approval and Breakthrough Therapy Designation hold the promise of making new treatments availa...
The rate of new drug approvals in the US has remained essentially constant since 1950, while the costs of drug development have soared. Many commentators question the sustainability of the current model of drug development, in which large pharmaceutical companies incur markedly escalating costs to deliver the same number of products to market. This Issue Brief summarizes the problem, describes ...
Title of Dissertation: Multiplicative Data Perturbation for Privacy Preserving Data Mining Kun Liu, Doctor of Philosophy, 2007 Dissertation directed by: Dr. Hillol Kargupta Associate Professor Department of Computer Science and Electrical Engineering Recent interest in the collection and monitoring of data using data mining technology for the purpose of security and business-related application...
Title of Dissertation: Privacy Preserving Distributed Data Mining based on Multi-objective Optimization and Algorithmic Game Theory Kamalika Das, Doctor of Philosophy, 2009 Thesis directed by: Dr. Hillol Kargupta Professor Department of Computer Science and Electrical Engineering Use of technology for data collection and analysis has seen an unprecedented growth in the last couple of decades. I...
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