Enlargement of the cochlear aqueduct is a controversial topic, with experienced investigators doubting its existence because of a lack of published cases. We describe the CT appearance of an enlarged cochlear aqueduct in a patient with advanced congenital inner ear anomalies and congenital hearing loss. The intent of this article is to present the CT appearance of a presumably enlarged cochlear...

various dimensions of the human vestibular aqueduct were evaluated in two groups, patient and control, and these measurements were compared. both groups were examined clinically, followed by audiometric evaluation and temporal bone high resolution ct scan. it was found that in approximately one third of the patient group (with idiopathic snhl), the vestibular aqueduct was 1.5 mm or larger. also...

Water molecules play a major role in the P450 catalytic cycle. Here, we locate the preferred water pathways and their gating mechanisms for the human cytochrome P450 3A4 (CYP3A4) and elucidate the role of the cytochrome P450 reductase (CPR) in turning on and activating these water channels. We perform explicit solvent molecular dynamic simulations of CYP3A4, unbound and bound to two substrates,...

A large vestibular aqueduct is one of the commonest radiological abnormalities of the inner ear. A case of acute profound unilateral sensorineural hearing loss and balance disturbance following minor head trauma in the presence of an abnormally enlarged vestibular aqueduct is described. The significance of a diagnosis of large vestibular aqueduct syndrome, in the presence of serviceable hearing...

Pneumocephalus has been reported after posterior fossa surgery especially with procedures performed in the sitting position. The gravitational effect is the decisive factor in the development of pneumocephalus. The entrapped air in the aqueduct may enlarge due to several factors such as elevated body temperature and may cause to deterioration in neurological status. We report a rare case of ten...

OBJECTIVE To characterize the appearance of the normal vestibular aqueduct on coronal computed tomography (CT). DESIGN Retrospective evaluation of routine CT images of the temporal bones. SETTING Private tertiary care center. PATIENTS Twenty-four children and young adults (14 females and 10 males), aged 2 to 24 years (average age, 10 years). MAIN OUTCOMES MEASURES Axial CT images were e...

Cyclophosphamide, a model teratogen, has been used to produce hydrocephalus experimentally by various researchers [1–4]. Although the precise mechanism of cyclophosphamide induced hydrocephalus remains elusive, hypertrophy of choroid plexus was considered as the primary cause [1,4]. Singh et al [4] observed agenesis or stenosis of the aqueduct as an associated reason. The present work has been ...

Large vestibular aqueduct syndrome (LVAS) is a distinct clinical entity characterized by fluctuative sensorineural hearing loss associated with isolated enlargement of the vestibular aqueduct. In this report, we present our experience with cochlear implantation in a patient with LVAS.