INTRODUCTION The ARCHITECT Anti-HCV assay is a fully automated high throughput chemiluminescent microparticle immunoassay (CMIA) for the detection of antibodies to structural and nonstructural proteins of the hepatitis C virus (HCV). To further enhance the performance of this test, the assay was modified to improve the specificity for blood donor specimens. METHODS The specificity of the enha...

Determination of the concentration of human luteinizing hormone plays an important role for the prediction of ovulation, evaluation of infertility, diagnosis of pituitary and gonadal disorders and in the differential diagnosis of puberty disorders. The ARCHITECT LH chemiluminescent-immunoassay for the quantitative determination of luteinizing hormone in human serum and plasma serves this clinic...

This paper discusses the work of the software architect by describing a software architect’s concerns and the documents that a software architect should produce. It proposes a definition of software architecture and discusses archtectural design criteria based on the idea that every architecture is expected to meet a specified set of goals. We start with a discussion of the meaning of “architec...

BACKGROUND Vitamin B12 (cobalamin) is a necessary cofactor in methionine and succinyl-CoA metabolism. Studies estimate the deficiency prevalence as high as 30% in the elderly population. Ten to thirty percent of circulating cobalamin is bound to transcobalamin (holotranscobalamin, holoTC) which can readily enter cells and is therefore considered the bioactive form. The objective of our study wa...

The foundation of every system is the architecture. It has to be designed according to the corresponding system requirements by the system architect who is also responsible for ensuring that it fits to the system requirements even if these change due to new conditions during development process. Our approach defines a model driven process for the architect to validate system architecture agains...