Abstract Glioblastoma (GBM) is a common, malignant brain tumor. While it rarely metastasizes to distant organs, the diffuse invasion of glioma cells within makes difficult resect. P21 (Waf-1) cyclin-dependent kinase inhibitor that plays an essential role in cell growth arrest, terminal differentiation, and apoptosis. Thus, existence natural variants p21 could be linked specific cancer. The purp...

background: the tumor suppressor gene tp53 (alias p53) located on chromosome 17 is involved in various cancers. case-control studies have shown that p53 codon 72 polymorphism modulates the prognosis and susceptibility to various malignancies. we undertook the present study to explore a possible association between mucinous and non-mucinous adenocarcinomas with different genotypes or alleles at ...

Yeast KEX2 protease was examined as a potential model for a human proprotein convertase and, in all respects, mimicked the predicted properties of a proalbumin convertase. The enzyme rapidly cleaved the propeptide Arg-Gly-Val-Phe-Arg-Arg from the NH2-terminal end of proalbumin but, unlike trypsin, failed to cleave physiologically unprocessed human proalbumin variants. There was little or no cle...

Chronic venous diseases (CVD), including varicose veins, are among the most common in developed countries Europe and United States affect one third to half of population, especially women. Among many achievements knowledge pathogenesis achievements, it should be noted identification role matrix metalloproteinases (MMPs) as important mediators degenerative process associated with onset progressi...

Objective: We developed a simple non-invasive I-123-N-isopropyl-p-iodoamphetamine (123I-IMP) quantification method by analyzing chest RI-angiography and single photon emission computed tomography (SPECT) images based on the microsphere model (SIMS method). Theoretically, the SIMS method could be changed to the simple non-invasive ARG (SIARG) method by modifying the integrated washout ratio (WR)...

pistachio green stink bug, acrosternum hegeeri, due to its inflicting damages on crop quantity and quality, is of a great economical importance in pistachio production. on the other hand, a knowledge of digestive enzymes, is quite indispensable in the study and application of new pest management technologies. results of studeies have shown that midgut in this insect is divided into four section...

The aim of the study was to compare effect glyproline peptides RGRGP (Arg-Gly-Arg-Gly-Pro), RGP (Arg-GlyPro), PRPGP (Pro-Arg-Pro-Gly-Pro) and PGPL (Pro-Gly-Pro-Leu) peptide substances at various concentrations on free radical oxidation intensity brain tissues Wistar males after intraperitoneal administration solutions traumatic injury. Material methods . tissue aged 2–3 months ( n = 126) were u...

320 one-day male broilers (ross 308) were divided in 4 treatments (with 4 replicate and 20 chicks for a replicate). all of broilers reared under a cold environmental temperature to induce ascites .experimental treatments were included 1: was fed a commercial corn-soybean meal- based diet meeting nrc (1994) including 1.2% arg and 40 iu of vitamin e/kg (control), 2: control with 400 iu of vitamin...