A new protocol for the aromatization of tetrahydrocarbazoles has been achieved using a catalytic amount of iodine, giving high yields. The role of iodine in the aromatization has been explained by DFT, and its wide scope is extended to the total synthesis of glycozoline and murrayafoline A. This method has proven to be tolerant of a broad range of functional groups.

A synthesis of moracin M using Appel dehydration a biomimetic inspired endoperoxide and subsequent late stage aromatization, is described. key 1,3-diene, obtained from base-free Suzuki-Miyaura coupling, can undergo oxidation to its endoperoxide, followed by under conditions aromatization give benzofuran, with deprotection then providing in only 4-steps. Alternatively, this 1,3‑diene synthetic r...

A platinum-catalyzed reaction involving new aromatization/1,3-carbonyl shift cascade of 2-epoxy-1-(methoxyalk-2-ynyl)benzenes is reported. This skeletal rearrangement is mechanistically significant because it involves a remarkable 1,3-carbonyl shift to complete the aromatization and to regenerate the catalyst.

Stable enols were synthesized from the reaction of (1Z,3Z)-1,4-dilithio-1,3-dienes with acid chlorides and structurally characterized by single-crystal X-ray analysis. These stable enols were formed by a novel de-aromatization/Michael addition/re-aromatization domino process.

In order to characterize aromatization in vivo, an androgen and an estrogen, labeled with different radioactive isotopes, are administered simultaneously, either as a pulse alone or as a pulse followed by a constant infusion of the same radiolabeled steroids. Subsequently, blood samples are obtained at varying time intervals and analyzed for the 3H/14C ratio in nonmetabolized unconjugated estro...

In order to characterize aromatization in vivo, an androgen and an estrogen, labeled with different radioactive isotopes, are administered simultaneously, either as a pulse alone or as a pulse followed by a constant infusion of the same radiolabeled steroids. Subsequently, blood samples are obtained at varying time intervals and analyzed for the 3H/14C ratio in nonmetabolized unconjugated estro...

A compound catalyst (RA) consisted of Ni, ZnO and HZSM-5 with functions of reactive adsorption desulfurization (RADS) and olefin aromatization for fluid catalytic cracking (FCC) gasoline upgrading was prepared. X-ray powder diffraction (XRD), temperature-programmed reduction and low-temperature N2 adsorption were used to characterize the properties of the catalysts. Performance evaluation by FC...

An enzyme which catalyzes the aromatization of cyclohexanecarboxyl coenzyme A has been isolated from whole liver as well as from liver mitochondria. Incubation of the soluble, partially purified enzyme with cyclohexanecarboxyl-CoA produces cyclohexene-l-carboxyl-CoA, benzoyl-CoA, and a polar compound which has not. been further characterized. All three isomers of cyclohexenecarboxyl-CoA are con...

The high concentrations of estradiol i !•'. ,i found in breast tumors of postmenopausal women could be the result of enhanced uptake from plasma or in situ aromatization of androgens to estrogens. To test the relative importance of these two mechanisms, a model system allowing precise distinction between each is required. Such a model was established using aromatase (A + )and sham (A-)-transf...

The high concentrations of estradiol (E2) found in breast tumors of postmenopausal women could be the result of enhanced uptake from plasma or in situ aromatization of androgens to estrogens. To test the relative importance of these two mechanisms, a model system allowing precise distinction between each is required. Such a model was established using aromatase (A+)- and sham (A-)-transfected M...