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Direct binding of WD40 repeat of Embryonic Ectoderm Development (EED) in the Polycomb Repressor Complex 2 (PRC2) to the histone H3 tail regulates the H3K27 methyltrasnferase activity of PRC2. The binding activity is required for the methylation of H3K27 over long distance of a Drosophila chromosome from the UBX (Hox gene) promoter to the PBX upstream enhancer region, implying EED initiates prop...
Background Several health organizations have adopted the 5A's brief intervention model (Ask, Advise, Assess, Assist, Arrange), based on evidence-based guidelines for smoking cessation. We examine individual, cognitive, behavioral, and organizational factors associated with the 5A's performance among clinical healthcare workers in Catalonia. We also investigate how these factors interact and pot...
This study analyzes regional structuring policies with the formation of candidates for New Autonomous Region (DOB) in West Java Province. The territorial arrangement is considered important to improve public services, increase welfare, equitable development, and bring span control closer. There are currently 27 district city governments Province that unequal serve 49.94 million inhabitants (202...
In June 2013, Brazil faced the largest and most significant mass protests in a generation. These were exacerbated by the population's disenchantment towards its highly fragmented party system, which is composed by a very large number of political parties. Under these circumstances, presidents are constrained by informal coalition governments, bringing very harmful consequences to the country. I...
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