Background: Phosphodiesterases (PDEs) play a major role in the regulation of cyclic adenosine monophosphate (cAMP)- and cyclic guanosine monophosphate (cGMP)-mediated pathways. Their inhibitors exhibit anti-inflammatory, vasodilatory and antithrombotic effects. Therefore, consumption of foods with PDE-inhibiting potential may possess beneficial influence on the risk of cardiovascular diseases. ...

Background: Type 2 diabetes mellitus with hyperlipidemia is a common disease. Conventional anti-hyperglycemic and anti-hyperlipidemic drugs have limited efficacies and important side effects, so that alternative agents are needed. Previous studies suggest that fiber-free artichoke (Cynara scolymus L.) leaf extract may have anti-hyperglycemic and anti-hypercholesterolemic effects in hypercholest...

A study was conducted to evaluate the effects of an artichoke extract on broiler production performance traits by comparing the results of two inclusion rates in broiler diets from 0 to 21 days of age. A total of 2880 day-old male broiler chicks was randomly assigned to 36 floor-pens and raised from 1 to 42 days of age. The CONTROL group received a comsoya meal basal diet. In the treatment diet...

The aim of this work was to characterise the phenolic compounds in artichoke (hearts) by using HPLC coupled to DAD-ESI-QTOF-MS, which proved useful in characterising 61 phenolic and other polar compounds. Notably, of the 61 compounds characterised, 34 new phenolic compounds with their isomers have been tentatively characterised in artichoke for the first time, namely: 3 hydroxybenzoic acids, 17...

background and aims: artichoke (cynara scolymus l.) is a plant of the asteraceae family. this plant is used in herbal medicine. this study was conducted to evaluate the effect of artichokeextract on insulin, glucagon, glucose, alkaline phosphatase (alp), alanine amino transferase (alt) and aspartate amino transferase (ast) in streptozotocin-induced diabetic rats. methods: in this experimental s...

Cynara scolymus L. is a medicinal plant frequently used in traditional medicine for liver diseases. The aim of this study is to evaluate the antimicrobial activity of the different parts of Artichoke. Maximum antimicrobial activity was observed with methanolic extract of bound phenols for (bract and heart) against Gram negative bacteria. The MIC values for bound phenols from heart were (63μg/ml...

Nitric oxide (NO) produced by endothelial nitric-oxide synthase (eNOS) represents an antithrombotic and anti-atherosclerotic principle in the vasculature. Hence, an enhanced expression of eNOS in response to pharmacological interventions could provide protection against cardiovascular diseases. In EA.hy 926 cells, a cell line derived from human umbilical vein endothelial cells (HUVECs), an arti...

Background: Strenuous acute exercise induces oxidative stress in the active muscles and circulation, However, consumption of products rich in antioxidants may potentially ameliorate these effects. Objective: The present investigation was conducted to determine the effect of Artichoke (Cynara scolymus L.) extract on oxidative stress and antioxidant defense after aerobic exercise in young athle...

BACKGROUND Hypercholesterolaemia is directly associated with an increased risk for coronary heart disease and other sequelae of atherosclerosis. Artichoke leaf extract (ALE) has been implicated in lowering cholesterol levels. Whether ALE is truly effective for this indication is still a matter of debate. This is an update of a review first published in 2002 and last updated in 2009. OBJECTIVE...