(Diacetoxyiodo)benzene has been used as an efficient catalyst for an improved and rapid one-pot synthesis of biscoumarin derivatives in excellent yield under reflux condition using water as a environmentally benign reaction medium. This aqua mediated Knoevenagel condensation of various aromatic and hetero-aromatic aldehydes with 4-hydroxycoumarin using catalytic amount of (diacetoxyiodo)benzene...

BACKGROUND Azaheterocycles are an important class of compounds because of their highly potent medicinal activities, and the imidazole subcategory is of special interest in regard to drug discovery research. FINDINGS An expeditious synthetic protocol of 2-aryl-4-phenyl-1H-imidazoles has been accomplished by reacting phenylglyoxal monohydrate, ammonium acetate, and aldehyde under sonication. Fo...

The reaction of aryl aldehydes with allylsilanes in the presence of boron trihalides produces haloallylated products. Mechanistic details are presented.

Abstract A new method for the fast synthesis of diverse 4-aryl-6-cycloamino-1,3,5-triazin-2-amines was developed. The is performed under microwave irradiation in a one-pot manner from cyanoguanidine, aromatic aldehydes, and cyclic amines. Their three-component reaction presence hydrochloric acid produced dihydrotriazines, which were then converted (without isolation) into targeted compounds via...

The brucine N-oxide promoted Morita-Baylis-Hillman (MBH) reaction of vinyl ketones with aldehydes has been achieved. The corresponding asymmetric version of MBH reaction was also investigated, and the electron-deficient aryl aldehydes have emerged as suitable reaction partners for vinyl ketones; where proline was employed as a co-catalyst. In this dual catalyst system, proline is believed to fo...

Chiral aryl methyl sulfoxides proved to be efficient activators in the asymmetric allylation of aldehydes with allyl trichlorosilanes. High enantioselectivity was found in the case of electron-poor aldehydes. The high levels of diastereoselectivity and the detection of nonlinear effects have allowed the elucidation of some mechanistic aspects of the reaction.

p2o5-sio2 (30% w/w) was found to be a useful catalyst for the synthesis of various 2-substituted aryl benzimidazoles under solvent-less and in solvent conditions from o-phenylenediamine and aldehydes. the products were directly recrystallized from methanol.

an efficient method has been developed for the catalysis of condensation of 1,2-phenylenediamines and 2-aminothiophenoles with different aldehydes into their corresponding 2-aryl-1h-benzimidazoles and 2-aryl-1h-benzothiazoles under mild condition. in this method, trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane (dhpdmdo)/hoac/ki system was used as a novel and effective oxidant in water at roo...

A simple, fast, efficient and eco-friendly procedure was developed for the synthesis of alkyl and aryl-N-methylnitrones. The corresponding nitrones of aromatic aldehydes, aliphatic aldehydes and alicyclic carbonyl compounds were prepared from N-methylhydroxylamine hydrochloride and Na2CO3-Na2SO4 by simply grinding at room temperature without using solvent.

A series of new push-pull compounds were synthesised by reaction of 5-aryl- furan-2-carboxaldehydes and furo[b]pyrrole type aldehydes with benzothiazolium salts. These new condensation products represent highly conjugated systems that have potential biological activity. The reaction of furo[b]pyrrole type aldehydes with benzothiazolium salts give potential precursors of cyanine dyes.