نتایج جستجو برای: arylalkylamine
تعداد نتایج: 171 فیلتر نتایج به سال:
this is the first description of the polymorphisms of arylalkylamine-n-acetyltransferase (aa-nat) gene in indian goats with different reproductive traits (twinning percentage and age of sexual maturity). based on the important role of aa-nat in reproduction, it is considered as a possible candidate gene for this trait. two novel synonymous snps, c825t (exon2) and c1249t (exon3) were identified....
Abused arylalkylamines fall into two major categories: the indolealkylamines, and the phenylalkylamines: These agents can be further subclassified on the basis of chemical structure. Examples of these agents possess hallucinogenic, stimulant, and other actions. Drug-discrimination techniques have been used to classify and investigate this large family of agents. Such studies have allowed the fo...
The arylalkylamine N-acetyltransferase (AANAT) is a key enzyme in the rhythmic production of melatonin. Two Aanats are expressed in Teleost fish (Aanat1 in the retina and Aanat2 in the pineal organ) but only Aanat1 is found in tetrapods. This study reports the cloning of Aanat1 from R. perezi. Transcripts were mainly expressed in the retina, diencephalon, intestine and testis. In the retina and...
The hallmarks of insulin action are the stimulation and suppression of anabolic and catabolic responses, respectively. These responses are orchestrated by the insulin pathway and are initiated by the binding of insulin to the insulin receptor, which leads to activation of the receptor's intrinsic tyrosine kinase. Severe defects in the insulin pathway, such as in types A and B and advanced type ...
Arylalkylamine N-acetyltransferase (AANAT) catalyzes the penultimate step in the biosynthesis of melatonin and other N-acetylarylalkylamides from the corresponding arylalkylamine and acetyl-CoA. The N-acetylation of arylalkylamines is a critical step in Drosophila melanogaster for the inactivation of the bioactive amines and the sclerotization of the cuticle. Two AANAT variants (AANATA and AANA...
This paper describes the role 14-3-3 proteins play in vertebrate photoneuroendocrine transduction. 14-3-3 proteins form a complex with arylalkylamine N-acetyltransferase (AANAT), the enzyme which turns melatonin production on during the day and off at night. Complex formation is triggered at night by cAMP-dependent phosphorylation of the enzyme, and results in activation and protection against ...
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