Background: Hepatocyte Growth Factor (HGF) and its receptor, Mesothelial-Epithelial Transition (cMet) factor signaling, play an essential role in controlling synaptogenesis.  Objectives: Because of the vital role of HGF and Met signaling in synaptogenesis and spatial learning function of the brain’s hippocampal region, we aimed to study the HGF and soluble cMet (s-cMet) serum levels in childre...

Autism spectrum disorder (ASD) is a mental condition, present from early childhood, characterized by great difficulty in communicating and forming relationships with others and using language. In the last four decades many studies have shown that immune responses in different regions of brain play an important role in ASD pathogenicity. A conservative estimate based on the research suggests tha...

Background: The prevalence of autism spectrum disorder (ASD) as a child neurodevelopmental disorder has increased significantly during the past 3 decades worldwide and in Iran. This chronic disease does not cause premature death and there is no definitive treatment. Thus, the cost of ASD is extremely heavy and overwhelming. The purpose of this study is to calculate the economic burden of ASD in...

Objectives: Studies around the world have shown that having a child with disability impacts a mother’s time use. The purpose of this study was to compare the time use of mothers of children with Autism Spectrum Disorder (ASD) with mothers of typically developing children. Methods: Eighty-four Iranian mothers (42 with ASD children and 42 with typically developing children) completed the M...

Objectives: Cerebral hemispheres functioning have been found to be abnormal in children with ASD. The role of lateralization in implicit and explicit motor learning has received little attention in ASD researches. The main goal of this study is investigating the differences between two hands implicit and explicit motor learning in children with ASD and typical matched group. Methods: In the ...

The present study reviewed the literature about intervention programs for Autism Spectrum Disorder (ASD) among children. ASD is a long-term neurodevelopment disorder that is identified as impairment in the context of social communication and interaction, and the predominance of restricted and repetitive patterns of behavior, interests or activities. Intervention programs have objectives such as...