human t-cell lymphotropic virus type 1 (htlv-1) is associated with adult t-cell leukemia/lymphoma (atl) and htlv-1-associated myelopathy/tropical spastic paraparesis (ham/tsp). only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic and ham/tsp is the most common clinical manifestation of the virus. ham/tsp is an inflamma...

We demonstrate a significantly high incidence of human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM)-or tropical spastic paraparesis (TSP)-like symptoms in WKA rats after injection with HTLV-1-producing MT-2 cells, while no symptoms were observed in F344 rats injected with MT-2 cells or in control WKA rats. Five of the eight (63%) WKA rats injected with MT-2 cells showed HAM...

The medical treatment of eight patients with paraparesis associated with Paget's disease of the vertebrae is described. Treatment, for 3 to 87 months, with calcitonin or with diphosphonates produced marked clinical improvement in seven of these patients. From this series and a review of 19 additional case reports it is concluded that favourable clinical response is seen in about 90 per cent of ...

A 53-year-old woman with tropical spastic paraparesis (also called human T-lymphotropic virus–associated myelopathy) reported several months of worsening weakness of the legs and feet, which had led to her use of a wheelchair. On examination, she was found to have severe spasticity and weakness of both legs and feet, bilateral Babinski sign, and bilateral patellar clonus (see video). The result...

Human T lymphotropic virus type I (HTLV-I) is a retrovirus which is associated with adult T cells leukaemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a minority of HTLV-I-infected individuals. It is not clear why a minority of HTLV-I-infected individuals develop HAM/TSP and majority remains lifelong carriers. It seems that the interaction between the virus...

recurrent spontaneous rupture of the urinary bladder has rarely been reported in english articles. this condition may be difficult to diagnosis before a laparotomy due to acute peritonitis. herein we describe a case of recurrent spontaneous rupture of the bladder in a 39-year-old woman with human t-lymphotropic virus type 1 (htlv-1) -associated myelopathy/topical spastic paraparesis (ham/tsp).

BACKGROUND The spastic paraparesis associated to HTLV-1 causes degenerative pyramidal tract lesions of the spinal cord and affects cortical-nuclear connections in the brain. AIM To report the findings of magnetic resonance imaging in patients with spastic paraparesis. MATERIAL AND METHODS A magnetic resonance imaging of the brain and spinal cord was performed in 30 patients (24 females), me...