Statins are known to inhibit growth of a number of cancer cells, but their mechanism of action is not well established. In this study, human prostate adenocarcinoma PC-3 and breast adenocarcinoma MCF-7 cell lines were used as models to investigate the mechanism of action of atorvastatin, one of the statins. Atorvastatin was found to induce apoptosis in PC-3 cells at a concentration of 1 μM, and...

BACKGROUND Torcetrapib, an inhibitor of cholesteryl ester transfer protein, may reduce atherosclerotic vascular disease by increasing levels of high-density lipoprotein (HDL) cholesterol. METHODS A total of 850 patients with heterozygous familial hypercholesterolemia underwent B-mode ultrasonography at baseline and at follow-up to measure changes in carotid intima-media thickness. The patient...

Few data are present in the literature on the relationship between atorvastatin use and acute pancreatitis. The aim of this study was to explore this issue in Taiwan. Using representative claims data established from the Taiwan National Health Insurance Program, this case-control study consisted of 5810 cases aged 20 to 84 years with a first-time diagnosis of acute pancreatitis during the perio...

background: the most common clinical indication of aminoglycosides (ag) is the treatment of serious gram?negative infections.the aim of this study was to evaluate plausible effects of atorvastatin on the biomarkers of acute kidney injury (aki) in patients receiving amikacin. materials and methods: in this double?blinded randomized clinical trial, fifty patients (25 in each group) receiving amik...

Obesity causes many problems such as cardiovascular and chronic kidney diseases. The aim of this study was to evaluate the efficacy of retinoic acid and atorvastatin co-administration in kidneys protection against high-fat diet induced damage. Twenty-five male Wistar rats (200.00 ± 20.00 g) were divided into five groups: 1) Control (standard diet), 2) High-fat diet (cholesterol 1.00%, 75 days),...

Background: In the current scenario, emergence of antimicrobial resistance has made it difficult to treat bacterial infections alone using antibacterial agents. Methods: Milk samples collected from 100 mastitis affected cows August 2018 June 2019 and were stored at 4°C. After species confirmation, isolates subjected ABST screened for genes - mecA, blaTEM PCR. Minimum Inhibitory Concentration (M...

Objective: The objective of the study was to evaluate the dose dependent effects of atorvastatin on rat kidneys. Methods: The selected doses of atorvastatin were administered orally for 17 days to rats. The statin induced nephrotoxicity was accessed by carrying out renal function tests and is by renal histopathology analysis. Measurements of antioxidant enzymes were also carried out to check wh...

chronic idiopathic urticaria is defined as recurrent hives occurring for at least 6 weeks. in  the  majority of  cases, there  is no  identifiable underlying etiology despite  extensive evaluation. a subset of these patients is classified as having autoimmune urticaria defined by the presence of a functional igg antibody to the α subunit of the high-affinity ige receptor (fceria) or to ige. the...

Aminoglycosides are still widely used for treatment of gram-negative sepsis in critically ill patients. The most reported electrolyte abnormalities related to these drugs are hypokalemia, hypomagnesemia, and hypocalcemia. In this study potential benefit of atorvastatin in prevention of amikacin-induced electrolytes imbalances has been evaluated. In this trial 44 patients were assigned to the at...

In the present study, we tested our hypothesis that atorvastatin exerts its anti-inflammation effect via suppressing LPS-induced rapid upregulation of Toll-like receptor 4 (TLR4) mRNA and its downstream p38, ERK, and NF-κB signaling pathways in human umbilical-vein endothelial cells (HUVECs) and human aortic endothelial cells (HAECs). TLR4 mRNA expression and its downstream kinase activities in...