gene association studies are less appealing in cancer compared to autoimmune diseases. complexity, heterogeneity, variation in histological types, age at onset, short survival, and acute versus chronic conditions are cancer related factors which are different from an organ specific autoimmune disease, such as grave’s disease, on which a large body of multicentre data is accumulated. for years t...

The aim of this study was to evaluate whether there are thyroid diseases in which breast cancer will appear later as well the role autoimmunity. This a retrospective observational study. A total 410 females (thyroid surgery and cancer) 524 only) were compared with regard pathological findings, hormones, autoimmunity type cancer. Thyroid autoimmunity, especially antithyroid peroxidase antibodies...

hemophagocytic syndrome (hps) is an uncommon manifestation in systemic lupus erythematosus (sle). clinical features of hps include fever, pancytopenia, abnormal liver enzyme, hepatosplenomegaly, lymphadenopathy, and coagulation disorder. hps comprises primary and reactive forms. herein, we describe a case of untreated sle with hps as one of the first manifestations of systemic lupus.

background: the relationship between thyroid autoimmunity and breast cancer is a challenging subject. we aimed to investigate this association in women with breast cancer. methods: in this descriptive study, 41 women with newly diagnosed breast cancer before receiving any pharmacologic treatment and 38 healthy age-matched women were enrolled. anti tpo ab (anti-thyroid peroxidase antibodies), ft...

multiple sclerosis (ms) is characterized by multiple areas of inflammation, demyelination and neurodegeneration. infiltrating th1 cd4+ t cells secrete proinflammatory cytokines. they stimulate the release of some cytokines, expression of adhesion molecules and these cytokines may cause damage to the myelin sheath and axons. in this study, we analyzed plasma levels and gene expressions of five i...

background: inappropriate activation or blockage of the inhibition of complement system could cause tissue damages in autoimmune diseases particularly rheumatoid arthritis (ra). defect in complement component regulation may cause damages to tissues, on the other hand, or the damaged tissue might affect the unnecessary activation of complement components.   objective: to investigate the expressi...

MicroRNAs (miRNAs) are small preserved non-coding RNA molecules that regulate gene expression post-transcriptionally by targeting the 3' UTR of mRNAs for translational repression or degradation. The rising evidence has established the significant role of miRNAs within the regulation of immune system and the prevention of autoimmunity. MiR-146a has obtained an importance as a modulator of differ...

Autoimmune diseases comprise a large, diverse group of diseases characterized by a humoral or cell-mediated immune response against the constituents of the body's own tissues. In cases in which the host is sensitized with a tissue-specific antigen, a single pathological immune reaction occurs in the target organ. In those cases in which the host is sensitized with either a single tissue nonspec...