نتایج جستجو برای: azelaic acid
تعداد نتایج: 747450 فیلتر نتایج به سال:
Introduction: Topical antimicrobials, such as clindamycin, are effective in the treatment of acne and azelaic acid, due to the lack of bacterial resistance, could be a useful alternative in topical treatment of acne. The aim of this study was to compare the effect of topical azelaic acid 20% with clindamycin 1% lotion for the treatment of acne. Method: This randomized clinical trial study was p...
Background: Skin flap grafting is a popular approach for reconstruction of critical skin and underlying soft tissue injuries. In a previous study, we demonstrated the beneficial effects of two 5α-reductase inhibitors, azelaic acid and finasteride, on tissue survival in a rat model of skin flap grafting. In the current study, we investigated the involvement of nitric oxide and inducible nitric o...
Backgound and Aim: One important limitation of random pattern skin flap in plastic surgery is the necrosis of distant parts of the flap resulting from ischemia. This effect cause unwanted increase in the costs and hospitalization. Previously, large number of factors has been evaluated to decrease the flap necrosis. In present study we used two drugs. Main reason was their mechanism of action th...
Background: Melasma is an acquired therapeutically problematicdisease characterized by symmetrical facial hypermelanosis. Theaim of this study was to evaluate the efficacy of azelaic acid20% cream in the treatment of melasma in Iranian patients andcompare it with hydroquinone 4% cream which has been thestandard treatment.Method: The study was an open clinical trial with a split-facedesign. All ...
Following reports of the successful management of cutaneous malignant melanoma with azelaic acid both locally and systemically a trial was undertaken to assess its value in the treatment of similar lesions involving the eye and its adnexa. Systemically administered azelaic acid failed to influence the melanomata in any of the 4 patients included in the study. A plea is made for the reporting ev...
In this study, the effect of exogenpous Azelaic acid and potassium phosphite on some antioxidant enzymes activity, lignin synthesis and metabolic pathways were investigated in Eryngium caucasicum. This experiment was performed in a completely randomized design in controlled consitions. Plants at the three-leaf stage were treated with potassium phosphite (2 g/L) and azelaic acid (1 mM) by sprayi...
Introduction: Melasma is a recurrent, symmetric, and chronic acquired hyperpimentation that presents gray-brown macules and patches with determined margins in areas exposed to light. There are many treatment options with different efficacies and side effects. In this study the therapeutic effect of 20% azelaic acid and 4% hydroquinone in treatment of melasma was assessed. Methods: In this cl...
In the course of research and development of a new pharmaceutical formulation of azelaic acid in the liposomal form, we developed a rapid and accurate method for the detection of impurities using high-performance liquid chromatography. A chromatographic column from Merck (Purospher Star RP C18, 250-4 mm (5 μm) was used in the assay, and the mobile phase gradient consisted of three phases: A--me...
Despite all modern surgical techniques, skin flap that is considered as the main method in most reconstructive surgeries puts the skin tissue at danger of necrosis and apoptosis derived from ischemia. Therefore, finding a treatment for decreasing the apoptosis derived from flap ischemia will be useful in clinic. In present study, we evaluated the effect of azelaic acid 20% and finasteride on ex...
in this study the influence of azelaic acid (aza) 20% cream on the sebum excretion rate (ser) of 80 volunteers having mild to moderate acne vulgaris was demonstrated. absorbent paper and sebutape were used to collect the sebum and quantification was carried out by direct gravimetric method. it was shown that topical application of aza creams could reduce the ser and number of acneic lesions as ...
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