Aplysia motor neurons B1, B2, and B15 synthesize the small cardioactive peptides A and B (SCPs). In previous studies using semi-intact preparations we have demonstrated that the SCPs are released from B15. Significant peptide release only occurred when B15 was stimulated at a high frequency or at lower frequencies with a long burst duration. In the behaving animal B15 fires in patterns expected...

To gain insights into the physiological role of cotransmission, we measured peptide release from cell B15, a motorneuron that utilizes ACh as its primary transmitter but also contains putative peptide cotransmitters, the small cardioactive peptides (SCPs) and the buccalins (BUCs). All stimulation parameters used were in the range in which B15 fires in freely moving animals. We stimulated neuron...

Both 5-HT and the 9 amino acid neuropeptide SCPb modulate 3 ionic currents in B15, enhancing a voltage-dependent inward sodium current, decreasing an outward potassium current and increasing an inward rectifying potassium current. In contrast, FMRFamide decreases a voltage-dependent inward sodium current and increases an outward potassium current. We have also investigated the roles of several ...

School of Life & Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK School of Cancer Studies, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, Department of Pharmacology and Toxicology, Radboud University ...

BY H. SHUM1,*, E. A. GAFFNEY1,2 AND D. J. SMITH2,3 1Mathematical Institute, University of Oxford, 24-29 St Giles’, Oxford OX1 3LB, UK 2Centre for Human Reproductive Science, Birmingham Women’s National Health Service Foundation Trust, Metchley Park Road, Edgbaston, Birmingham B15 2TG, UK 3School of Mathematics and School of Clinical and Experimental Medicine, University of Birmingham, Edgbaston...

A. Pranzetti, Dr. C. L. Yeung, Prof. P. M. Mendes School of Chemical Engineering University of Birmingham Edgbaston, Birmingham B15 2TT , UK E-mail: [email protected] Prof. J. A. Preece School of Chemistry University of Birmingham Edgbaston, Birmingham B15 2TT , UK M. Davis, Prof. P. Koelsch National ESCA and Surface Analysis Center for Biomedical Problems Department of Bioengineering Unive...

†Author for correspondence 1Clinical Trial Coordinator, Cancer Research UK Clinical Trials Unit, Institute for Cancer Studies, The University of Birmingham, B15 2TT, UK Tel: +44 121 414 3797 Fax: +44 121 414 3700 [email protected] 2Senior Lecturer in Medical Oncology, Cancer Research UK Clinical Trials Unit, Institute for Cancer Studies, The University of Birmingham, B15 2TT, UK Tel: +44 121...

The functional activity of even simple cellular ensembles is often controlled by surprisingly complex networks of neuromodulators. One such network has been extensively studied in the accessory radula closer (ARC) neuromuscular system of Aplysia. The ARC muscle is innervated by two motor neurons, B15 and B16, which release modulatory peptide cotransmitters to shape ACh-mediated contractions of ...

OBJECTIVE Human leucocyte antigen (HLA) B27 and HLA-B15 are associated with spondyloarthritis (SpA). Recent Assessment of SpondyloArthritis international Society (ASAS) criteria emphasise a distinction between SpA with axial and peripheral patterns. We analysed whether HLA-A, HLA-B and HLA-DRB1 alleles could associate with these patterns. METHODS We studied 100 healthy individuals and 178 pat...