DNA- and RNA-processing pathways are integrated and interconnected in the eukaryotic nucleus to allow efficient gene expression and to maintain genomic stability. The recruitment of DNA Topoisomerase I (Topo I), an enzyme controlling DNA supercoiling and acting as a specific kinase for the SR-protein family of splicing factors, to highly transcribed loci represents a mechanism by which transcri...

Deciphering the role of alternative splicing in developmental processes relies on the identification of key genes whose expression is controlled by splicing regulators throughout the growth of a whole organism. Modulating the expression levels of five SR proteins in the developing eye of Drosophila melanogaster revealed that these splicing factors induce various phenotypic alterations in eye or...

Epidemiological data, family history, clinical data, and HLA typing were studied in three groups of patients with Behçet's syndrome: six Israeli Ashkenazi Jews, 29 non-Ashkenazi Jews, and three Israeli Arabs. HLA-B51 and B52 were present in 24/38 (63%) and 8/38 (21%), respectively, of the patients compared with 13/151 (9%) of the control group for both cases, a relative risk of 18.2 and 2.8 res...

The genetic programs specifying eye development are highly conserved during evolution and involve the vertebrate Pax-6 gene and its Drosophila melanogaster homolog eyeless (ey). Here we report that the SR protein B52/SRp55 controls a novel developmentally regulated splicing event of eyeless that is crucial for eye growth and specification in Drosophila. B52/SRp55 generates two isoforms of eyele...

BACKGROUND Takayasu arteritis and ulcerative colitis are immune-mediated inflammatory diseases; genetic factors are assumed to play an important role in the pathogenesis of these 2 diseases. However, the coexistence of these 2 diseases has rarely been reported. CASE REPORT In this report, we present a rare case of a 29-year-old man with a 4 years history of ulcerative colitis who developed Ta...

OBJECTIVES To determine the frequency of different HLA-antigens in patients with plaque psoriasis in the Omani Arab population. METHODS Fifty four Omani patients clinically diagnosed with plaque psoriasis attending the dermatology outpatient clinic in Al-Nahdah Hospital (the tertiary dermatology centre in Oman) were selected for HLA studies. RESULTS HLA-B52 was present in 20.4% of patients ...

Objetivos. Evaluar los cambios de expresión COX-1 y COX-2 en fibroblastos gingivales infectados con citomegalovirus.Métodos. Se cultivaron humanos primarios criopreservados se confirmó su fenotipo mesenquimal mediante inmunofluorescencia para vimentina. Posteriormente infectaron a una multiplicidad infección (MOI) 0,5 dos cepas CMV: cepa laboratorio (Towne) un aislado clínico (B52). Las células...

STUDY OBJECTIVE Respiratory disturbance caused by ARDS has been reported during administration of granulocyte-colony stimulating factor. The clinical features of such respiratory distress were investigated in this study. DESIGN Retrospective case review. SETTING A 1,100-bed university teaching hospital. PATIENTS Five patients who had dyspnea caused by ARDS develop after chemotherapy or bo...

Bacillus licheniformis strain CG-B52 was isolated as the etiological agent producing a self-limited outbreak of high mortalities in commercial Litopenaeus vannamei culture ponds on the Colombian Caribbean coast in 2005. Here, we report its draft genome and three novel extrachromosomal elements that it harbors.

The present note includes explanatory comments about the synergic interaction within the sphere of the socioeconomic analysis between the two following theoretical frameworks: 1. The Darwinian evolutionary model. 2. The computer simulation in accordance with the principia established by Bruno de Finetti and Herbert Simon. J.E.L. Classification: O33, C63, B52