background: recent studies indicate an increased incidence of pertussis disease in recent years. the aim of this study was to evaluate the efficacy of the acellular vaccine for children (as a replacement of current whole cell vaccine in the expanded program on immunization) and for high-risk adults in iran through updating current best available evidence.   methods: we performed a systematic li...

results the results showed that all the strains had the dominant allele ptxs1a. there were differences between the alleles of the clinical strains and the vaccine strain. conclusions in recent years, a significant increase in the incidence of pertussis has been reported worldwide. our findings regarding the allelic shift of the ptxs1 gene are similar to those reported in many european and ameri...

results bahaodowle razi, a persian physician from the 15th century anno domini (ad), reported two epidemics in harat and one in rey (inold persia) for the first time, one century before baillou. he named it as sorfe-ie-am (meaning public cough). those occurred during his lifetime. explaining about his observations and experiences about this epidemic, bahaodowle razi elaborated on prognosis, sym...

conclusions herbal compounds, such as zm mixtures, are acceptably efficacious in cough relief with fewer adverse effects than chemical compounds in the treatment of cold-related cough, especially in infants and younger children. patients and methods a total of 52 pediatric patients (2 - 12 years old) with common colds were included in the study. the patients were randomly divided into two treat...

chronic cough is a common problem in patients visiting physicians and its prevalence in different populations range from 3 to 40%. postnasal drip, asthma and gastroesophageal reflux are the known cause of chronic cough. although diagnosis of asthma is usually made by clinical signs and spirometeric results, methacholine challenge test is a good diagnostic test in patients who show normal physic...