Vaults are 13 million Da ribonucleoprotein particles with a highly conserved structure. Expression and assembly by multimerization of an estimated 96 copies of a single protein, termed the major vault protein (MVP), is sufficient to form the minimal structure and entire exterior shell of the barrel-shaped vault particle. Multiple copies of two additional proteins, VPARP and TEP1, and a small un...

Vaults are barrel-shaped cytoplasmic ribonucleoprotein particles that are composed of a major vault protein (MVP), two minor vault proteins [telomerase-associated protein 1 (TEP1), vault poly(ADP-ribose) polymerase (VPARP)] and small untranslated RNA molecules. Not all expressed TEP1 and VPARP in cells is bound to vaults. TEP1 is known to associate with the telomerase complex, whereas VPARP is ...

The present work presents and discusses an analysis of the floor types Villa Diomedes (Pompeii archaeological park in Campania region, Italy) from architectural, archaeological, structural point view. In particular, geometrical-structural parameters different rules used by ancient builders to design them are investigated means interdisciplinary research. links between assumptions, archival sour...

The barrel vaults are composed of member elements arranged on a cylindrical surface. This kind of structure is utilized to cover the long spans. In this paper, the hybrid charge system search and particle swarm optimization algorithm is improved and utilized to optimal design of single-layer barrel vault frames. Some modifications on parameter values are performed to enhance the performance of ...

in this paper, the problem of simultaneous shape and size optimization of single-layer barrel vault frames which contains both of discrete and continuous variables is addressed. in this method, the improved magnetic charged system search (imcss) is utilized as the optimization algorithm and the open application programming interface (oapi) plays the role of interfacing analysis software with th...

In this paper the authors analysed four single-layered braced barrel vaults with different types of bracing. Each vault covered area 20 m × 28 and was made from steel hollow sections. The static-strength analyses structures were conducted using Autodesk Robot Structural Analysis program, taking into account self-weight, glass cover, snow load wind load. case load, pressure perpendicular to long...

During interphase growth of eukaryotic cells, nuclear pore complexes (NPCs) are continuously incorporated into the intact nuclear envelope (NE) by mechanisms that are largely unknown. De novo formation of NPCs involves local fusion events between the inner and outer nuclear membrane, formation of a transcisternal membranous channel of defined diameter and the coordinated assembly of hundreds of...

Abstract. In this paper the effectiveness of application a hemp biocomposite reinforcement at extrados masonry barrel vault was investigated. To aim, two specimens unreinforced (UV) and reinforced (RV) vaults were built having same geometry with brickwork material subjected to shaking table seismic tests. The comparison dynamic behavior between carried out by increasing intensity input, which s...

The vault complex is a ubiquitous 13-MDa ribonucleoprotein assembly, composed of three proteins (TEP1, 240 kDa; VPARP, 193 kDa; and MVP, 100 kDa) that are highly conserved in eukaryotes and an untranslated RNA (vRNA). The vault has been shown to affect multidrug resistance in cancer cells, and one particular component, MVP, is thought to play a role in the transport of drug from the nucleus. To...