The prevalence of obesity among adults and children has increased steadily over the last few years worldwide, reaching epidemic proportions. Particularly alarming is the link between obesity and the development of chronic disorders such as heart disease, type 2 diabetes, hypertension and some cancers (Bjorntorp, 1997). Environmental causes of obesity are thought to include a sedentary lifestyle...

The regionalization of the vertebrate hindbrain involves a segmentation process, well conserved through vertebrate evolution (Gilland and Baker, 1993). During early hindbrain development, a series of morphological units, termed rhombomeres (r), forms along the anteroposterior axis (Hanneman et al., 1988; Lumsden and Keynes, 1989). The rhombomeres serve to organize segmental patterns of neuronal...

J. Clin. Invest. © The American Society for Clinical Investigation, Inc. 0021-9738/96/04/1788/07 $2.00 Volume 97, Number 8, April 1996, 1788–1794 “Molecular Medicine in Genetically Engineered Animals” Series Editor, Kenneth R. Chien January 1 Gene modification via “plug and socket” gene targeting................................. Jada Lewis, Baoli Yang, Biological insights through genomics: mous...

J. Clin. Invest. © The American Society for Clinical Investigation, Inc. 0021-9738/96/03/1360/06 $2.00 Volume 97, Number 6, March 1996, 1360–1365 “Molecular Medicine in Genetically Engineered Animals” Series Editor, Kenneth R. Chien January 1 Gene modification via “plug and socket” gene targeting................................. Jada Lewis, Baoli Yang, Biological insights through genomics: mous...

We have previously shown differences in the intracellular targeting of alpha2a (alpha(2A))- and alpha2c (alpha(2C))-adrenoreceptors expressed in the same cell line (von Zastrow, M., Link, R., Daunt, D. , Barsh, G., and Kobilka, B. (1993) J. Biol. Chem. 268, 763-766; Daunt, D. A., Hurt, C., Hein, L., Kallio, J., Feng, F., and Kobilka, B. K. (1997) Mol. Pharmacol. 51, 711-720). alpha(2A)-Adrenore...

January 1 Gene modification via “plug and socket” gene targeting.................................. Jada Lewis, Baoli Yang, ......................................................................................................................... Pete Detloff, and Oliver Smithies January 15 Biological insights through genomics: mouse to man ...................................... Edward M. Rubin a...

The recessive mouse mutation kreisler affects hindbrain segmentation and inner ear development in homozygous mice. The mouse gene affected by the mutation was found to encode a basic domain leucine-zipper (bZIP)-type transcription factor of the Maf-family named kr (Cordes, S.P. and Barsh, G.S. (1994) Cell 79, 1025-1034). The avian bZIP transcription factor mafB, which shows high homology to kr,...

H ow the zebra got its stripes is a frequent topic in popular literature about the natural world. For developmental biologists, however, it is much easier to study the biology of pattern formation in zebrafish, where the tools of experimental embryology and genetics have proved to be very useful. Now, in eLife, David Parichy from the University of Washington and coworkers – including Dae Seok E...

The child of Western-trained engineers, Lin He grew up in a Beijing very different from today's skyscraper megalopolis. She recalls the freedom of the outdoors, the remnants of ancient city walls, and the fl ying kites. Like many others born in that era, He aspired to become an important scientist like the mathematicians and technologists who were then China's national heroes. Having long plann...

Eating disorders and obesity are urgent public health problem with a high burden of diseases for our societies. Core symptoms are unhealthy eating habits, with disturbances of eating behavior, and inability to control body weight. Food intake and energy balance are controlled as a complex, redundant, regulatory system ensuring that the amount of ingested calories does not exceed what the body c...