aintaining acid base balance presents a considerable challenge to the growing neonate. The infant ust ingest protein for growth and development. The metabolism of sulfur containing amino acids eads to the production of protons that must be secreted by the kidney. In addition, the formation of ydroxyapatite for the mineralization of growing bone also leads to acid production. Thus, the rowing in...

The acid-base status of intensive care patients is monitored on the basis of three quantities. The graphical representation which may be of help for the monitoring task is therefore cumbersome. The classical Siggaard-Andersen acid-base chart is such a representation, but it is only suited for evaluating one acid-base status at a time and not for representing acid-base paths. A new representatio...

The clinical features, arterial blood gases, and acid-base profile were examined in 229 consecutive episodes of acute asthma in 170 patients who required hospitalization. A simple respiratory alkalosis was the most common acid-base disturbance, occurring in 48 percent of the episodes. Metabolic acidosis, either alone or as part of a mixed disturbance, was noted in 28 percent. Of 60 episodes pre...

Severe acid-base disorders combined with electrolyte disturbances are of ten seen in patients with hyperosmolar hyperglycaemic state (HHS) or diabetic ketoacidosis (DKA). Acid-base disorders and electrolyte disturbances are tightly connected [1]. The aims of this clinical lesson are (i) to give insight in the relation between hyperglycemia, acid-base disturbances and electrolyte homeostasis, (i...

This report describes the historical development in the clinical application of chemical variables for the interpretation of acid-base disturbances. The pH concept was already introduced in 1909. Following World War II, disagreements concerning the definition of acids and bases occurred, and since then two strategies have been competing. Danish scientists in 1923 defined an acid as a substance ...

Acid-base disturbances are very common in critically ill and injured patients as well as contribute significantly to morbidity and mortality. An understanding of the pathophysiology of these disorders is vital to their proper management. This review will discuss the etiology, pathophysiology and treatment of acid-base disturbances in intensive care patients--with particular attention to evidenc...

Background: Electrolyte and acid-base disturbances are common in critically ill patients. Their relationship with hospital mortality has not been clearly clarified. Methods: A retrospective propensity score matched analysis was used to evaluate the effects of electrolyte and acid-base disturbances on hospital mortality in critically ill patients from 2014 to 2015 in our hospital. Multiple logis...