Background—Alterations in Ca-handling proteins are thought to underlie the deranged Ca transients that contribute to deterioration of cardiac function in congestive heart failure (CHF). Clinical trials in CHF patients have shown that treatment with b-adrenergic receptor antagonists (bB) improves cardiac performance. The present study determined whether the abundance of Ca-handling proteins is d...

b a ckground:  the purpose of our study was to investigate the possible effect of  bsm i vitamin d receptor (vdr’s) polymorphism on changes of the inflammatory and oxidative stress (os) biomarkers in response to daily intake of vitamin d- fortified yogurt drink ( doogh ) in subjects with type 2 diabetes (t2d). m ethods : in a randomized controlled trial, 100 t2d subjects were allocated to two g...

When beta adrenergic receptor blocker (BB) is stopped abruptly, tachycardia, blood pressure raise, increased number of anginal attacks, worsening of HF symptoms, etc. may ensue, which is known as “BB rebound phenomenon”. Thus, the aim of the paper is four-fold: to review the topic (BB rebound phenomenon); to illustrate BB rebound presence in everyday practice; to provide Guidelines’ view on BB ...

The finding that liver necrosis caused by the environmental glutathione (GSH)-depleting chemical, bromobenzene (BB) is associated with marked impairment in O- and S-methylation of BB metabolites in Syrian hamsters raises questions concerning the role of methyl deficiency in BB toxicity. N-Acetylmethionine (NAM) has proven to be an effective antidote against BB toxicity when given after liver GS...

OBJECTIVE Growing evidence has shown that vitamin D deficiency can cause lower bone mineral density (BMD) and an increased risk of osteoporosis. Vitamin D receptor (VDR) BsmI polymorphism (rs1544410) can affect BMD variation and circulating osteocalcin levels. To date, a wide range of epidemiological studies have been carried out to evaluate the association between VDR BsmI polymorphism and sus...

Ensuring building-block (BB) mixing is critical to the success of genetic and evolutionary algorithms. This study develops facetwise models to predict the BB mixing time and the population sizing dictated by BB mixing for single-point crossover. The population-sizing model suggests that for moderate-to-large problems, BB mixing – instead of BB decision making and BB supply – bounds the populati...

BACKGROUND there is evidence that the suspension of betablockers (BB) in decompensated heart failure may increase mortality. Dobutamine (dobuta) is the most commonly used inotrope in decompensation, however, BB and dobuta act with the same receptor with antagonist actions, and concurrent use of both drugs could hinder compensation. OBJECTIVE to evaluate whether the maintenance of BB associate...

Creatine kinase (CK) BB, a member of the CK gene family, is a predominantly cytosolic CK isoform in the brain and plays a key role in regulation of the ATP level in neural cells. CK BB levels are reduced in brain regions affected by neurodegeneration in Alzheimer's disease (AD), Pick's disease, and Lewy body dementia, and this reduction is not a result of decreased mRNA levels. This study demon...

As a growth regulator, PDGF-BB plays a crucial role in regulating neuronal survival and cell differentiation during embryonic development and in the adulthood. The multiple roles and mechanisms of PDGF-BB are still not known, especially involved in plasticity after spinal cord injury. However, before we can carry out further investigations a transgenic animal model with PDGF-BB down-regulation ...