Orbital lymphoma is rare and accounts for less than 1% of non-Hodgkins lymphomas (NHLs), and marginal zone Bcell lymphoma of the mucosa-associated lymphoid tissue (MALT) type ise the most common histological type involving the orbit. MALT lymphomas are indolent, and usually well response to local radiotherapy (RT). Results from RT series have demostrated excellent and durable local control and ...

B-lymphocyte stimulator (BLyS), a relatively recently recognized member of the tumor necrosis factor ligand family (TNF), is a potent cell-survival factor expressed in many hematopoietic cells. BLyS binds to 3 TNF-R receptors, TACI, BCMA, BAFF-R, to regulate B-cell survival, differentiation, and proliferation. The mechanisms involved in BLYS gene expression and regulation are still incompletely...

gastrointestinal tract, although other Bcell-derived non-Hodgkin lymphoma often occurs there. According to previous reports, gastrointestinal spread of mantle cell lymphoma frequently involves the colorectum and stomach; reports of small-intestinal involvement are rare. Consistent with preceding reports [1–3], the endoscopic appearance of colorectal and small-intestinal spread of mantle cell ly...

Sinonasal lymphoma is a rare disease with NK/T-cell (NKTC) or B-cell immunophenotype. Previous study revealed the geographic difference in frequency of NKTC lymphoma (NKTCL) and almost constant association with Epstein-Barr virus (EBV) infection. Through review of 41 cases with sinonasal lymphoproliferative diseases registered in the Department of Anatomical Pathology, University of Indonesia d...

Purpose: There remains an unmet therapeutic need for patients with relapsed/refractory diffuse large Bcell lymphoma (DLBCL). The purpose of this study was to evaluate the therapeutic potential of sepantronium bromide (YM155), a survivin suppressant, in combination with either bendamustine or both bendamustine and rituximab using DLBCL models. Experimental Design: Human DLBCL cell lines, DB, SU-...

Introduction: Primary cutaneous lymphomas (PCL) are a heterogeneous group of extra nodal non-Hodgkin lymphomas defined as malignant tumor derived from B, T or natural killer cells. Primary cutaneous follicle centre lymphoma (PCFCL), represents the most common type of primary cutaneous BCell Lymphomas. Case Report:We present the case of three female patients with facial PCFCL, all of them with e...

The transcription factor NFB is a tightly regulated positive mediator of Tand Bcell development, proliferation, and survival. The controlled activity of NFB is required for the coordination of physiologic immune responses. However, constitutive NFB activation can promote continuous lymphocyte proliferation and survival and has recently been recognized as a critical pathogenetic factor in lympho...

Expression of MDM2 during embryogenesis was studied in mice. During 14.5 to 18.5 days of prenatal development, the nasal respiratory epithelium expresses high levels of MDM2 RNA and protein in both wild type and p53 null embryos. MDM2 expression during development is tissue-specific and is independent of p53. The mdm2 basal mRNA expression appears relatively moderate in most organs in adult mic...

haematologica/the hematology journal | 2007; 92(12) | 1589 | Bor T-lymphocyte-mediated autoimmune disorders may lead to clinical disease characterized by low blood cell counts. The term autoimmune cytopenias has been collectively applied to this heterogeneous group of disorders. After the introduction of the humanized, chimeric monoclonal anti-CD20 antibody, rituximab, as a powerful therapeutic...