chronic granulomatous disease is an infrequent primary immunodeficiency characterized by defective intracellular killing of ingested microorganisms thereby making patients highly susceptible to recurrent lite threatening bacterial and fungal infections. in this study, we review the medical course of an 8 yr old girl with ar-cgd. she suffered from recurrent dermal and deep abscesses, retractable...

Abstract World Health Organisation recommends the practice of BCG vaccination at birth in countries which have a high incidence tuberculosis and/or leprosy burden. The is considered safe for competent immune system. However, children with weakened systems cause can be primary or secondary, vaccine may lead to side effects localized disseminated. In this study, we report spectrum inborn errors i...

BACKGROUND Primary immunodeficiency diseases (PIDs) are considered rare but are generally assumed to be more common in Middle Eastern countries. The prevalence and characteristics of PIDs are unknown in Oman. METHODS Sultan Qaboos University Hospital is the national referral center for PID in Oman during the study period. Patients were diagnosed and classified according to the clinical and la...

Background: Disseminated bacilli calmette-Guerin (BCG) infection after inoculation with live vaccine is considered to result from impaired immunity of the child. However, half of the cases are regarded as idiopathic because no well-defined immunodeficiency condition can account for the infection. Case report: An 8-month-old male infant was admitted with an ulcer on his left arm at the site ...

Susceptibility to infections caused by Mycobacterium tuberculosis and other Mycobacterium species has been reported in patients with acquired immunodeficiencies (e.g., acquired immunodeficiency syndrome, or AIDS) or primary immunodeficiency diseases (PIDs), including defects of the IL-12/IFNaxis, severe combined immunodeficiency (SCID), CD40L deficiency, and chronic granulomatous disease (CGD)....

UNLABELLED The only tuberculosis (TB) vaccine in use today, bacillus Calmette-Guérin (BCG), provides insufficient protection and can cause adverse events in immunocompromised individuals, such as BCGosis in HIV(+) newborns. We previously reported improved preclinical efficacy and safety of the recombinant vaccine candidate BCG ΔureC::hly, which secretes the pore-forming listeriolysin O of Liste...