Introduction: Memory impairment is one of the complications of diabetes which may accompany with changes in expression of apoptotic and antiapoptotic genes. The aim of the present study was the evaluation of intra-hippocampal injection of aminoguanidine (AG), as an antioxidant and inducible nitric oxide synthase inhibitor, on passive avoidance memory and Bcl-2 family genes expression in diab...

background: b cell cll/lymphoma 2 protein, bcl-2, is an important anti-apoptotic factor that has been implicated in lithium’s neuroprotective effect. however, most studies have focused on assessing the effects of lithium in neurons, ignoring examination of bcl-2 in astrocytes, which also influence neuronal survival and are affected in bipolar disorder. the aim of this study was to evaluate whet...

objective(s): menopause and diabetes obviously increase the risk of cardiovascular disease in women. the aims of the present study were to evaluate the effects of ovariectomy in type 2 diabetes on the histology and expression of mirna-29, mirna-133, igf-1 and bcl-2 genes and bcl-2 protein and caspase 3 activity in the hearts of female rats. materials and methods: forty female wistar rats were d...

statement of problem: the aggressive nature and high recurrence rate of odontogenic keratocysts (okcs) may be due to unknown factors inherent in the epithelium or because of enzymatic activity in the fibrous wall. bcl-2 protein is characterized by its ability to inhibit apoptosis. purpose: the aim of the present study was to analyze the expression of bcl-2 protein in okcs and to compare it with...

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unknown etiology affecting over 1% the US population. Deep epidermal infiltrative cysts and tunnels characteristic develop in intertriginous skin, with mixed immune infiltrate present inflamed regions, dominated by B T cells, but also including myeloid cells. Recent studies show progressive increase cells plasma as HS lesio...

introduction: although the initial hypothesis for the action of doxepin was based on the inhibition of the reuptake of neurotransmitters, it has been suggested that it may also involve other mechanisms. therefore, this study aims to investigate the effect of doxepin on spatial memory, tumor necrosis factor alpha (tnf-α) level, expression of pro-apoptotic (bad and bax) and anti-apoptotic (bcl-2)...

introduction: busulfan as a chemotherapeutic agent causes testicular germinal epithelium depletion and cytotoxicity in germ cells. the aim of this study was to assess antioxidant status, reactive oxygen species (ros) generation and apoptosis-related genetic markers of adult male mouse sperm following busulfan treatment. materials and methods: forty adult nmri mice (30 ± 5 g) were divided into t...

Background: Bax and Bcl-2 are the major members of Bcl-2 family whose play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction. Therefore, the balance between pro- and anti-apoptotic members of this family can determine the cellular fate. Methods: In this study, the relative level of mRNA expression of Bax and Bcl-2 genes was deter...

Abstract Introduction: Colorectal cancer is the third most prevalent malignancy with high mortality rate, necessitating markers that predict survival and guide the treatment. Previous studies have examined the immunohistochemical expression of Bcl-2, an apoptotic marker, in colorectal carcinoma, but results have been contradictory. Objectives: To evaluate the histopathological featu...