In the present study, the in vitro cytotoxicity of daidzein was evaluated in human BEL-7402, A549, HeLa, HepG-2 and MG-63 cancer cell lines. BEL-7402 cells were sensitive to daidzein treatment, with an IC50 value of 59.7±8.1 µM. Daidzein showed no cytotoxic activity toward A549, HeLa, HepG-2 and MG-63 cells. Daidzein increased the levels of reactive oxygen species (ROS) and induced a decrease i...

Epigenetic changes play a significant role in leukaemia pathogenesis, therefore histone deacetylases (HDACis) are widely accepted as an attractive strategy for acute promyelocytic leukaemia (APL) treatment. Belinostat (Bel, PXD101), a hydroxamate-type HDACi, has proved to be a promising cure in clinical trials for solid tumours and haematological malignancies. However, insight into molecular ef...

Automatic extraction of biological network information is one of the most desired and most complex tasks in biological text mining. The BioCreative track 4 provides training data and an evaluation environment for the extraction of causal relationships in Biological Expression Language (BEL). BEL is a modeling language that is easily editable by humans or by automatic systems and can express cau...

Environmental pollution assessment and control are priority issues for both developed and developing countries of the world. The use of plant material for a more complete picture of environmental health appears to be particularly appealing. Here we validate a previous plant-adapted Comet assay on leaf tissues of Nicotiana tabacum cultivars Bel B and Bel W3. The effects of H(2)O(2) on DNA damage...

Network-based approaches have become extremely important in systems biology to achieve a better understanding of biological mechanisms. For network representation, the Biological Expression Language (BEL) is well designed to collate findings from the scientific literature into biological network models. To facilitate encoding and biocuration of such findings in BEL, a BEL Information Extraction...

The assumptions needed to prove Cox’s Theorem are discussed and examined. Various sets of assumptions under which a Cox-style theorem can be proved are provided, although all are rather strong and, arguably, not natural. I recently wrote a paper (Halpern, 1999) casting doubt on how compelling a justification for probability is provided by Cox’s celebrated theorem (Cox, 1946). I have received (w...

The assumptions needed to prove Cox’s Theorem are discussed and examined. Various sets of assumptions under which a Cox-style theorem can be proved are provided, although all are rather strong and, arguably, not natural. I recently wrote a paper (Halpern, 1999) casting doubt on how compelling a justification for probability is provided by Cox’s celebrated theorem (Cox, 1946). I have received (w...

BACKGROUND Based on clinical medications and related studies, we established a Yang-Gan Jie-Du Sang-Jie (YGJDSJ) herbal formula for hepatocarcinoma treatment. In present study, we evaluated the anti-cancer potential of YGJDSJ on suspension-grown human hepatocellular carcinoma Bel-7402 cells. METHODS Bel-7402 cells were cultured in poly(2-hydroxyethyl methacrylate) (poly-HEMA) coated plates an...

OBJECTIVE MiR-183 acts as an oncomiR and is usually upregulated in hepatocellular cancer (HCC). This study aims to study the association between miR-183 dysregulation and multi-drug resistance (MDR). Also, how it is dysregulated in HCC cells was investigated. MATERIALS AND METHODS The association between miR-183 and HIF-1α in HCC cell line BEL-7402 and the multidrug-resistant variant BEL-7402...