We describe a new program called cryptic splice finder (CSF) that can reliably identify cryptic splice sites (css), so providing a useful tool to help investigate splicing mutations in genetic disease. We report that many css are not entirely dormant and are often already active at low levels in normal genes prior to their enhancement in genetic disease. We also report a fascinating correlation...

Coercion in psychiatry stems from the historic inequality between the psychiatrist and the person who is designated as the "patient," even though he/she may not have chosen this role, and may not see him/herself as needing psychiatric attention. The psychiatrist has the power to define an individual as mentally ill, and then to confine and treat the person based on that definition. The user/sur...

Several recent estimates of global biodiversity have concluded that the total number of species on Earth lies near the lower end of the wide range touted in previous decades. However, none of these recent estimates formally explore the real "elephant in the room", namely, what proportion of species are taxonomically invisible to conventional assessments, and thus, as undiagnosed cryptic species...

This is the third installment in a series of editorials on the implications of open-access publishing for established publishing practices and stakeholders in scientifi c and medical research. T he questions, tensions, and social concerns surrounding copyright and the Internet are very different for scientifi c and medical literature than for other kinds of easily reproducible digital works. Pe...

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Sequenced bacterial genomes are routinely found to contain gene clusters that are predicted to encode metabolites not seen in fermentation-based studies. Pseudomallei group Burkholderia are emerging pathogens whose genomes are particularly rich in cryptic natural product biosynthetic gene clusters. We systematically probed the influence of the cryptic secondary metabolome on the virulence of th...

SUMMARY Recent studies have shown that some digenean trematodes previously identified as single species due to the lack of distinguishing morphological characteristics actually consist of a number of genetically distinct cryptic species. We obtained mitochondrial 16S and nuclear ITS1 sequences for the redial stages of Acanthoparyphium sp. and Curtuteria australis collected from snails and whelk...