Abstract This study aims to analyze whether the high-fat diet decreases serum TNF-α and breast tumor area on benzopyrene induced mice (Mus musculus). was a true experimental with randomized posttest-only control group design using 36 female musculus), 3-4 months age, 25 ± 5 grams. Mice were (BZP) subcutaneously dose of 0.3mg/20gBB/day for 14 days in right area, then randomly divided into 6 grou...

This study investigated the profiling of polycyclic aromatic hydrocarbon- (PAH-) induced genotoxicity in cell lines and zebrafish. Each type of cells displayed different proportionality of apoptosis. Mitochondrial DNA (mtDNA) copy number was dramatically elevated after 5-day treatment of fluoranthene and pyrene. The notable deregulated proteins for PAHs exposure were displayed as follows: lamin...

AIM To investigate the effect of carvacrol on chemical carcinogenesis, cancer cell proliferation and platelet aggregation, and to find possible correlation between all these processes and the antioxidant properties of carvacrol. MATERIALS AND METHODS 3,4-benzopyrene-induced carcinogenesis model using Wistar rats was used. Leiomyosarcoma cells from Wistar rats were used to study carvacrol anti...

4, 8, 16, 18, 23, 24, 27, 30, 31), benzopyrene (presumably 3,4-benzopyrene)(13, 14, 17, 18, 26, 33), and 1,2,5,6dibenzanthracene (16, 18, 21 , 25). The relatively poor response of guinea pigs to the stimuli of carcinogenic chemicals has been attributed to an inherent species resis tance. Such claims were primarily based on a number of observations that spontaneous neoplasms were less frequent i...

-Pellets of 3,4-benzopyrene were implanted into the brain of equal numbers of normal and castrated male rats. The position of the implant was carefully controlled so that it impinged on the mitotically active sub-ependymal plate. A high proportion of glial tumours (77-8%) were induced in normal male rats. The effects of castration were to reduce the incidence of tumours (500) and to increase th...

This paper presents clinical, experimental, and epidemiologic evidence to help explain the rapidly increasing incidence of primary lung cancer, with recently observed reversal in leading cell type from squamous cell to adenocarcinoma. It postulates that this may be due to changes in modern cigarettes, with or without filters, which allow inhalation of increased amounts of radioactive lead and p...