▼ In recent years, the number of patients with type 2 diabetes mellitus caused by insulin resistance has continued to increase in Japan. Insulin resistance is considered to be closely related to the risk of cardiovascular diseases and atherosclerotic diseases, represented by arteriosclerosis obliterans (ASO). Therefore, improvement of insulin resistance is one of the important strategies in the...

OBJECTIVES The purpose of this study was to assess the safety and efficacy of the oral prostacyclin analogue beraprost sodium during a 12-month double-blind, randomized, placebo-controlled trial in patients with pulmonary arterial hypertension (PAH). BACKGROUND Pulmonary arterial hypertension is a progressive disease that ultimately causes right heart failure and death. Despite the risks from...

Selective COX-2 inhibitors are most widely used analgesic and anti-inflammatory drugs;however, its maximal use is highly associated with various serious abnormal cardiovascularevents. Beraprost sodium (BPS), prostacyclin analogue has been shown to vasodilatory,antiplatelates, anti-inflmmatory, and antioxidant activity. The objective of the present study wasto evaluate the effect of BPS on celec...

Selective COX-2 inhibitors are most widely used analgesic and anti-inflammatory drugs;however, its maximal use is highly associated with various serious abnormal cardiovascularevents. Beraprost sodium (BPS), prostacyclin analogue has been shown to vasodilatory,antiplatelates, anti-inflmmatory, and antioxidant activity. The objective of the present study wasto evaluate the effect of BPS on celec...

BACKGROUND This study evaluated the effects of Beraprost sodium (Berasil) on subjective leg symptoms in patients with peripheral arterial disease caused by diabetes mellitus. METHODS Ninety-four diabetic patients with peripheral arterial disease were treated with Beraprost in a fixed-dose, prospective, multicenter, cohort study. Beraprost (40 µg) was administered orally 3 times daily (120 µg/...

Received 8 December 2016, accepted 26 December 2016 Correspondence to: Sumiaki Tanaka, Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan E-mail: [email protected] Long-term survival of patients with pulmonary arterial hypertension associated with connective tissue disease: beneficia...

This paper provides an update on the mechanisms of vascular impairment associated with insulin resistance and the pathogenesis of diabetic nephropathy and peripheral artery disease (PAD). It also considers the optimal treatment strategies for systemic vascular protection in light of recent findings. This area is of major clinical importance given the ongoing global epidemic of type 2 diabetes a...