I read with great interest the recent publication by Bayraktar et al. [1] on nitric oxide (NO) in beta thalassemia minor. in which they reached the conclusion that “These findings confirm that plasma NO levels in betathalassemia minor patients are decreased at the time of diagnosis.” Bayraktar et al. also noted the possible usefulness of NO level in assessing the prognosis and follow-up evaluat...

INTRODUCTION Beta thalassemia is hereditary blood disorder which is due to a defect in beta globin gene with excess of free alpha globin chains which become abnormal components in maturing red blood cells (RBCs) leading to destruction of RBCs by the spleen with subsequent anemia. Patients with beta-thalassemia major require regular blood transfusions to survive. The primary long term complicati...

Examination of labeling patterns of proteins in Chinese hamster cells(line CHO) revealed the presence of a class of protein(s) that is synthesized during G1 phase of the cell cycle. Cells arrested in G1 by isoleucine (Ile) deprivation were prelabeded with [14-C]Ile, induced to traverse G1 by addition of unlabeled Ile, and labeled with [3-H]Ile at hourly intervals. Cells were fractionated into...

Between 1990 and 2000, nonfederol timberland orem in wegem Washington declined by 5%, in tontrml to a 3% reduciion for the 1980-90 period. Most of this reduction is attributed to the conversion of timberland io ofher lond uses, especially urban and other developed uses. In areas such os the Puget Sound region, population densities hove more than doubled over the lmt 40 yeon. Further expansion i...

Introduction Thalassemia is a group of genetic disorders resulting in the decreased production of globin chains, alpha or beta, leading to the decreased production of hemoglobin (Hb). For the heterozygous state, it can be recognized by the microcytosis of its red blood cell or the decreased mean corpuscular volume (MCV) of less than 80 fL. For alpha-thalassemia-1 or alpha(0)thalassemia traits, ...

Dear Editor, The problem of congenital hemoglobin disorder is common in tropical Asia. In tropical Southeast Asian countries, very high prevalence of thalassemia disorder especially for beta thalassemia is observed. This tropical hematological problem affects millions of population and cause several health disorders. Of interest, the issue of reproductive health impairment of the population wit...

Background: Hemoglobinopathies and betathalassemia is one of the most common autosomal disorders worldwide different molecular mechanisms, most of which are base substitution or small deletions or insertions of one or two nucleotides in the globin genes. It has been found that hemoglobinopathies and β-thalassemia mutations are relatively populations specific; each ethnic group has its own set o...

BACKGROUND High serum level of cancer antigen 15.3 (CA15.3) has been reported in some malignant and nonmalignant conditions including thalassemia major which could have been resulted from ineffective erythropoiesis. We aimed to evaluate the serum level of CA15.3 in carriers of beta-thalassemia by comparing them with cancer patients and healthy individuals. METHODS This cross-sectional study w...

Hemoglobinopathies are a group of hereditary hemolytic anemia characterized by qualitative (sickle cell disease) or quantitative (thalassemia) defects in the alpha or beta-globin chain synthesis. Homozygotes or compound heterozygotes for the mutated alpha or beta-globin genes can cause severe anemia at an early age. These pathologies are common in some areas (Mediterranean, Africa, India, and S...

Background and Objectives: Beta-thalassemia continues to be a cause of significant burden to the society particularly in the poorer developing countries. Although sophisticated methods of screening have become available, a hunt for a cheap, rapid, objective screening method still remains elusive. Thus, the objectives are to study the validity of Naked-Eye-Single-Tube-OsmoticFragility-Test (NEST...