ISSN:0975-1459 Bioanalytical method validation includes all of the procedures that demonstrate that a particular method used for a quantitative measurement of analytes in a given biological matrix is selective, sensitive, reliable and reproducible for the intended use. Any method developed for the analysis of analytes in biological fluids must yield consistent results despite the variations in ...

This paper is concerned with accurate computations for matrix multiplication. An error-free transformation of matrix multiplication is developed by the authors. It transforms a product of two floatingpoint matrices to a sum of several floating-point matrices by using only floating-point arithmetic. This transformation is useful not only for accurate matrix multiplication but also for interval e...

BACKGROUND The present study was performed to develop a scoring system for predicting cure status in patients with cutaneous leishmaniasis (CL). MATERIALS AND METHODS This study included 199 patients with CL from Skin Diseases and Leishmaniasis Research Center (Isfahan, Iran). Data were collected as longitudinal in each visit of patients. We applied ordinal logistic generalized estimating equ...

By proposing efficient methods for estimating Body Segment Inertial Parameters' (BSIP) estimation and validating them with a force plate, it is possible to improve the inverse dynamic computations that are necessary in multiple research areas. Until today a variety of studies have been conducted to improve BSIP estimation but to our knowledge a real validation has never been completely successf...

This Guideline proposes a protocol for the validation of forensic evaluation methods at the source level, using the Likelihood Ratio framework as defined within the Bayes' inference model. In the context of the inference of identity of source, the Likelihood Ratio is used to evaluate the strength of the evidence for a trace specimen, e.g. a fingermark, and a reference specimen, e.g. a fingerpri...

A bioanalytical method is a set of procedures involved in the collection, processing, storage, and analysis of a biological matrix for a chemical compound. The availability of selective and sensitive bioanalytical methods is a prerequisite for the generation of reliable data on pharmacokinetics, bioavailability, and bioequivalence of drugs. These methods should allow the quantification of drugs...

This paper describes bioanalytical methods and biosensors which rely on cholinesterase (ChE) inhibition and can be used to detect and test the toxicity of organophosphate (OP) and carbamate pesticides. Particular attention is given to the combined use of these methods and photothermal detection that has recently led to improved sensitivity and increased sample throughput of ChE bioanalytical as...