OBJECTIVE Nicotine replacement therapy (NRT) increases the probability of smoking cessation. This study was conducted to determine if three prototype 4-mg nicotine lozenges produced locally in India were bioequivalent to a globally marketed reference product, Nicorette® 4-mg nicotine lozenge. MATERIALS AND METHODS Healthy adult smokers (N = 39) were treated with three prototype 4-mg nicotine ...

Introduction. Telmisartan is widely used in clinical practice during hypertension treatment. It a specific angiotensin II receptor antagonist (type AT1), effective at oral intake, A bioequivalence study of Telzap ® and Mikardis was conducted with 60 volunteers. Aim. The purpose the trial comparative pharmacokinetics evidence (telmisartan, tablets 80 mg, Boehringer Ingelheim International GmbH, ...

OBJECTIVE This study was designed to demonstrate that alendronate (ALN)/vitamin D3 combination tablets (ALN/D5600) are bioequivalent to corresponding doses of ALN and vitamin D3 as individual tablets in healthy Taiwanese volunteers. METHODS In this open-label, randomized, 2-period, crossover study, 68 volunteers were randomized to a single ALN/D5600 combination tablet or corresponding doses o...

Compost, poultry litter, IPM Lab Biopesticide and BAU-Biofungicide, either alone or in combinations, were assessed for their effect in controlling early blight disease, and on growth and yield parameters of tomato. The lowest early blight incidence and severity were recorded in T13 (compost tea + poultry litter extract + BAU-Bio-fungicide) followed by T12 (compost tea + poultry litter extract +...

OBJECTIVE To compare the bioequivalent parameters of 30 mg pioglitazone tablets manufactured locally (Glista) and originally (Actos). MATERIAL AND METHOD A randomized, single dose, two-treatment, two-period, two-sequence crossover study was conducted Twenty-four healthy volunteers were recruited at Siriraj Clinical Research Unit. Each subject received a 30 mg pioglitazone tablet of both formu...

Introduction. A fixed dose combination of telmisartan and hydrochlorothiazide is indicated for treatment in the arterial hypertension. The these substances causes an additive effect that helps to reduce blood pressure. bioequivalence study Telzap ® Plus compared with MikardisPlus was conducted 63 volunteers. Aim. purpose trial a comparative pharmacokinetics evidence drug product (tablets 80 mg ...