Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated with insulin resistance, impaired insulin signaling, β-cell dysfunction, abnormal glucose levels, altered lipid metabolism, sub-clinical inflammation and increased oxidative stress. These and other unknown mechanisms lead to micro- and macro-complications, such as neuropathy, retinopathy, nephropathy an...

MACC1 is a prognostic and predictive metastasis biomarker for more than 20 solid cancer entities. However, its role in metabolism not sufficiently explored. Here, we report on how impacts the use of glucose, glutamine, lactate, pyruvate fatty acids show comprehensive analysis MACC1-driven metabolic networks. We analyzed concentration-dependent changes nutrient use, depletion, tracing employing ...

plants with hypoglycemic properties are important in the treatment of diabetes. one of the mechanisms in reducing blood glucose is preventing the digestive absorption of glucose. the aim of this study was to evaluate the antioxidant properties of some traditional medicinal plants collected from different regions of iran and their effects on glucose diffusion decrease. the amounts of phenolic co...

objective(s):the aim of this study was to evaluate, for the first time, whether the effects of low-dose adropin administration is effective in rats with hyperlipidemia. materials and methods: twenty one wistar albino female rats were randomly divided into 3 groups and fed with high-fat diet for 4 weeks to establish the hyperlipidemia model. meanwhile, adropin was administrated intraperitonealy ...

Background and objectivesToday, medicinal plants phytobiotics that contain flavonoids, alkaloids, essential oils are widely used in animal feed. These additives have many benefits, including increasing liver function preventing certain diseases. The is one of the organs plays a key role insulin-mediated regulation metabolism as well glucose, whole-body, lipid homeostasis. aim this study was to ...

Historically, hop cones (Humulus lupulus) have been used since ancient times as a remedy for many ailments and, as a source of polyphenols and bitter acids, is very effective in the treatment of metabolic syndrome (MS). Hop flavonoids, particularly xanthohumol (XN), are substances with hypoglycemic, antihyperlipidemic, and antiobesity activities. Iso-α-acids (IAA) and matured hop bitter acids (...

There is very limited information on cytochrome P450 (P450)-mediated oxidative metabolism of dietary flavonoids in humans. In this study, we used human liver microsomes and recombinant P450 isoforms to examine the metabolism of two flavonols, galangin and kaempferide, and one flavone, chrysin. Both galangin and kaempferide, but not chrysin, were oxidized by human liver microsomes to kaempferol,...

There is very limited information on cytochrome P450 (P450)-mediated oxidative metabolism of dietary flavonoids in humans. In this study, we used human liver microsomes and recombinant P450 isoforms to examine the metabolism of two flavonols, galangin and kaempferide, and one flavone, chrysin. Both galangin and kaempferide, but not chrysin, were oxidized by human liver microsomes to kaempferol,...

Flavonoids are a class of chemically related polyphenols that are nearly ubiquitous in nature. Of the more-than 4000 flavonoids thus identified, citrus fruit-derived flavonoids are suggested to have an inverse association with the occurrence of coronary heart disease via their ability to reduce plasma cholesterol concentrations. Our current studies examined whether citrus flavonoids possess an ...