We report multifunctional optical imaging using dye-coated gold nanorods. Three types of useful information, namely, Raman, fluorescence signals, and absorption contrast, can be obtained from a phantom experiment. These three kinds of information are detected in a nanoparticle-doped-phantom using diffuse optical imaging. Our novel nanoparticle could be used as a multimodality marker for future ...

Medical physicists have made many important contributions to biomedical research. In medical imaging physics, important contributions include the development of advanced imaging methods in such areas as functional MRI, proton and phosphorus spectroscopy, diffusion tensor imaging, optical imaging, digital radiography, and near-infrared spectroscopy. The radiation imaging techniques have received...

  Context: In recent years, nanotechnology has opened up several new avenues of extraordinary biomedical potential by modulating metals into their nanosize leading to significant improvement in their chemical, physical and optical properties. Introduction: <span style="color...

The editors introduce the Biomedical Optics Express feature issue, "In Vivo Microcirculation Imaging," which includes 14 contributions from the biomedical optics community, covering such imaging techniques as optical coherence tomography, photoacoustic microscopy, laser Doppler /speckle imaging, and near infrared spectroscopy and fluorescence imaging.

This review article is meant to help biomedical engineers and nonphysical scientists better understand the principles of, and the main trends in modern scanning and imaging modalities used in ophthalmology. It is intended to ease the communication between physicists, medical doctors and engineers, and hopefully encourage "classical" biomedical engineers to generate new ideas and to initiate pro...

Over the last couple of years molecular imaging has been rapidly developed to study physiological and pathological processes in vivo at the cellular and molecular levels. Among molecular imaging modalities, optical imaging stands out for its unique advantages, especially performance and cost-effectiveness. Bioluminescence tomography (BLT) is an emerging optical imaging mode with promising biome...

The telecentric lens, which was originally used in the machine vision industry, has often been utilized in biomedical imaging systems due to its commonly known properties, such as large transverse field of view, constant magnification, and long working distance. However, its potential advantages in optical imaging of biological tissue, which is highly diffusive, have not been fully explored. We...

The noninvasiveness of nonlinear optical imaging techniques is quantified in terms of the number of free electron generated in the laser-tissue interaction region per photon emitted into the nonlinear optical signal. For a broad variety of biomarker dyes and bioactivity reporter proteins, this ratio is shown to approach a critical value of unity for field intensities above 1 TW/cm2. Closed-form...

Photoacoustic (PA) imaging is a hybrid biomedical imaging method that exploits both acoustical Epub ahead of print and optical properties and can provide both functional and structural information. Therefore, PA imaging can complement other imaging methods, such as ultrasound imaging, fluorescence imaging, optical coherence tomography, and multi-photon microscopy. This article reviews technique...